Coenzyme Q10 inhibits the aging of mesenchymal stem cells induced by D-galactose through Akt/mTOR signaling

Oxidative Medicine and Cellular Longevity
Dayong ZhangJian-Ping Pan

Abstract

Increasing evidences indicate that reactive oxygen species are the main factor promoting stem cell aging. Recent studies have demonstrated that coenzyme Q10 (CoQ10) plays a positive role in organ and cellular aging. However, the potential for CoQ10 to protect stem cell aging has not been fully evaluated, and the mechanisms of cell senescence inhibited by CoQ10 are still poorly understood. Our previous study had indicated that D-galactose (D-gal) can remarkably induce mesenchymal stem cell (MSC) aging through promoting intracellular ROS generation. In this study, we showed that CoQ10 could significantly inhibit MSC aging induced by D-gal. Moreover, in the CoQ10 group, the expression of p-Akt and p-mTOR was clearly reduced compared with that in the D-gal group. However, after Akt activating by CA-Akt plasmid, the senescence-cell number in the CoQ10 group was significantly higher than that in the control group. These results indicated that CoQ10 could inhibit D-gal-induced MSC aging through the Akt/mTOR signaling.

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Citations

Mar 1, 2016·Kidney International·LaTonya J HicksonLilach O Lerman
Apr 19, 2016·Environmental Toxicology·Pei-Yu ChenChih-Yang Huang
Jun 13, 2015·Oxidative Medicine and Cellular Longevity·Kenneth Maiese
Oct 16, 2015·British Journal of Clinical Pharmacology·Kenneth Maiese
Nov 2, 2019·Clinical and Experimental Pharmacology & Physiology·Dayong ZhangJianping Pan
Dec 30, 2016·Chinese Medical Sciences Journal = Chung-kuo I Hsüeh K'o Hsüeh Tsa Chih·Guo-Wen LiKai Qing
Jun 29, 2017·Molecular Medicine Reports·Dayong ZhangJianping Pan
Aug 18, 2018·Oxidative Medicine and Cellular Longevity·Jia HuoKeiichi Higuchi

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Methods Mentioned

BETA
Transfections
transfection
protein assay

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