PMID: 15354396Sep 10, 2004Paper

Coenzyme Q10 serum levels in Huntington's disease

Journal of Neural Transmission. Supplementum
J AndrichTh Müller

Abstract

Mitochondrial dysfunction contributes to the neurodegenerative process in Huntington's disease (HD). Coenzyme Q10 (CoQ10) enhances mitochondrial complex I activity and may therefore provide a therapeutic benefit in HD. We compared serum CoQ10 levels of previously untreated-and treated HD patients with those of healthy controls. CoQ10 did not significantly (ANCOVA F(dF 2, dF 55) = 2.57; p=0.086) differ between all three groups. However, the post hoc analysis showed no significant (p = 0.4) difference between treated HD patients ([CoQ10]: 88.12 [mean]+/-24.44 [SD], [range] 48.75-146.32 [pg/million platelets]) and controls (93.71+/-20.72, 65.31-157.94), however previously untreated HD patients (70.10+/-21.12, 38.67-106.14) had marked (p = 0.051) lower CoQ10 results than treated HD patients and controls (p = 0.017). Our results support that CoQ10 supplementation in HD patients may reduce impaired mitochondrial function in HD.

Citations

Sep 1, 2006·Neurochemical Research·Pilar del HoyoFélix Javier Jiménez-Jiménez
May 14, 2010·Journal of Bioenergetics and Biomembranes·Mritunjay PandeyRajamma Usha
Apr 4, 2019·Frontiers in Molecular Neuroscience·Bindu D Paul, Solomon H Snyder
May 22, 2018·Expert Review of Molecular Diagnostics·Delia YuberoRafael Artuch
Dec 13, 2018·Nutritional Neuroscience·Áine MaguireMichael Gill
Jan 17, 2020·Brain Sciences·Ashok KumarJong-Joo Kim
Nov 18, 2005·Neurochemistry International·Svatava KasparováAnna Gvozdjáková
Oct 8, 2021·Environmental Science and Pollution Research International·Rahul TripathiPravir Kumar

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