Coenzyme Q10 supplementation alleviates pain in pregabalin-treated fibromyalgia patients via reducing brain activity and mitochondrial dysfunction

Free Radical Research
Passakorn SawaddirukSiriporn C Chattipakorn

Abstract

Although coenzyme Q10 (CoQ10) supplementation has shown to reduce pain levels in chronic pain, the effects of CoQ10 supplementation on pain, anxiety, brain activity, mitochondrial oxidative stress, antioxidants, and inflammation in pregabalin-treated fibromyalgia (FM) patients have not clearly elucidated. We hypothesised that CoQ10 supplementation reduced pain better than pregabalin alone via reducing brain activity, mitochondrial oxidative stress, inflammation, and increasing antioxidant levels in pregabalin-treated FM patients. A double-blind randomised placebo-controlled trial was conducted. Eleven FM patients were enrolled with 2 weeks wash-out then randomly allocated to 2 treatment groups; pregabalin with CoQ10 or pregabalin with placebo for 40 d. Then, patients in CoQ10 group were switched to placebo, and patients in placebo group were switched to CoQ10 for another 40 d. Pain pressure threshold (PPT), FM questionnaire, anxiety, and pain score were examined. Peripheral blood mononuclear cells (PBMCs) were isolated to investigate mitochondrial oxidative stress and inflammation at day 0, 40, and 80. The level of antioxidants and brain positron emission tomography (PET) scan were also determined at these time points. Pregabal...Continue Reading

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Citations

Feb 6, 2020·Antioxidants·Marta GoschorskaDariusz Chlubek
Jul 23, 2020·Microcirculation : the Official Journal of the Microcirculatory Society, Inc·Lei LiHeyong Zhao
Oct 2, 2020·International Journal of Molecular Sciences·Kyung Hee LeeBae Hwan Lee
Dec 11, 2020·Oxidative Medicine and Cellular Longevity·Nan YangXiao-Yuan Mao
May 1, 2021·International Journal of Molecular Sciences·Rosalba SiracusaDaniela Impellizzeri
Sep 10, 2021·Pain Practice : the Official Journal of World Institute of Pain·Nicoletta MarchesiMassimo Allegri

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