Coenzyme Q10 supplementation reduces peripheral oxidative stress and inflammation in interferon-β1a-treated multiple sclerosis

Therapeutic Advances in Neurological Disorders
Marcello MocciaVincenzo Brescia Morra

Abstract

Oxidative stress is a driver of multiple sclerosis (MS) pathology. We evaluated the effect of coenzyme Q10 (CoQ10) on laboratory markers of oxidative stress and inflammation, and on MS clinical severity. We included 60 relapsing-remitting patients with MS treated with interferon beta1a 44μg (IFN-β1a) with CoQ10 for 3 months, and with IFN-β1a 44μg alone for 3 more months (in an open-label crossover design). At baseline and at the 3 and 6-month visits, we measured markers of scavenging activity, oxidative damage and inflammation in the peripheral blood, and collected data on disease severity. After 3 months, CoQ10 supplementation was associated with improved scavenging activity (as mediated by uric acid), reduced intracellular reactive oxygen species production, reduced oxidative DNA damage, and a shift towards a more anti-inflammatory milieu in the peripheral blood [with higher interleukin (IL)-4 and IL-13, and lower eotaxin, granulocyte-macrophage colony-stimulating factor (GM-CSF), hepatocyte growth factor (HGF), interferon (IFN)-γ, IL-1α, IL-2R, IL-9, IL-17F, macrophage inflammatory proteins (MIP)-1α, regulated on activation-normal T cell expressed and secreted (RANTES), tumor necrosis factor (TNF)-α, and vascular endothelial...Continue Reading

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Apr 18, 2020·Expert Opinion on Investigational Drugs·Pablo Villoslada, Lawrence Steinman
May 20, 2020·The Cochrane Database of Systematic Reviews·Natalie E ParksBradley C Johnston
Jul 1, 2020·International Journal of Molecular Sciences·Ekaterina ProshkinaAlexey Moskalev
Aug 23, 2020·International Journal of Molecular Sciences·Maryam GulAmmar Chaudhry
May 18, 2020·International Journal of Environmental Research and Public Health·Marcello MocciaRaffaele Palladino
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Jan 31, 2020·Journal of Nutrition and Metabolism·Michiyo TakahashiToshikazu Suzuki
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May 6, 2021·Therapeutic Advances in Neurological Disorders·Stefanie Haase, Ralf A Linker
Oct 2, 2021·Naunyn-Schmiedeberg's Archives of Pharmacology·Nilima PradhanArti Singh

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Methods Mentioned

BETA
enzyme-linked immunosorbent assay

Software Mentioned

Stata
Excel
Flow
Jo

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