Coevolution of Domain Interactions in the Chloroplast TGD1, 2, 3 Lipid Transfer Complex Specific to Brassicaceae and Poaceae Plants

The Plant Cell
Yang YangChristoph Benning

Abstract

The import of lipids into the chloroplast is essential for photosynthetic membrane biogenesis. This process requires an ABC transporter in the inner envelope membrane with three subunits, TRIGALACTOSYLDIACYLGLYCEROL (TGD) 1, 2, and 3, named after the oligogalactolipids that accumulate in the respective Arabidopsis thaliana mutants. Unlike Arabidopsis, in the model grass Brachypodium distachyon, chloroplast lipid biosynthesis is largely dependent on imported precursors, resulting in a characteristic difference in chloroplast lipid acyl composition between the two plants. Accordingly, Arabidopsis is designated as a 16:3 (acyl carbons:double bounds) plant and Brachypodium as an 18:3 plant. Repression of TGD1 (BdTGD1) in Brachypodium affected growth without triggering oligogalactolipid biosynthesis. Moreover, expressing BdTGD1 in the Arabidopsis tgd1-1 mutant restored some phenotypes but did not reverse oligogalactolipid biosynthesis. A 27-amino acid loop (L45) is solely responsible for the incomplete functioning of BdTGD1 in Arabidopsis tgd1-1 Coevolutionary analysis and coimmunoprecipitation assays showed that the TGD1 L45 loop interacts with the mycobacterial cell entry domain of TGD2. To explain the observed differences in olig...Continue Reading

Citations

Aug 21, 2020·Plant Signaling & Behavior·Jinlu LiNa Sui
Aug 22, 2018·Proceedings of the National Academy of Sciences of the United States of America·Juntaro NegiKoh Iba
Jan 29, 2019·Plant & Cell Physiology·A A Lavell, C Benning
May 8, 2019·The Plant Journal : for Cell and Molecular Biology·Anastasiya LavellChristoph Benning
Sep 29, 2021·The Plant Journal : for Cell and Molecular Biology·Anastasiya LavellChristoph Benning

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