Coevolution of host and virus: the pathogenesis of virulent and attenuated strains of myxoma virus in resistant and susceptible European rabbits

Virology
S M Best, P J Kerr

Abstract

Myxoma virus was introduced into the European rabbit population of Australia in 1950. Although the virus was initially highly lethal in rabbits, there was rapid selection for less virulent strains of virus and innately resistant rabbits. To investigate the basis of resistance to myxoma virus, we have compared the pathogensis of the virulent strain of myxoma virus originally released into Australia and an attenuated, naturally derived field strain of myxoma virus. This was done in laboratory rabbits, which have not been selected for resistance, and in wild rabbits that have developed significant resistance. Wild rabbits were able to recover from infection with virus that was always lethal in laboratory rabbits. Laboratory rabbits were able to control and recover from infection with attenuated virus. This virus caused a trivial disease in wild rabbits. There was little difference between laboratory and wild rabbits in titers of either virulent or attenuated virus in the skin at the inoculation site. However, resistant wild rabbits had a 10- to 100-fold lower titer of virulent virus within the lymph node draining the inoculation site and controlled virus replication in tissues distal to the draining lymph node. Replication of viru...Continue Reading

References

Sep 1, 1990·Cellular Immunology·K A LaybournD S Strayer
May 1, 1989·Virology·R J Russell, S J Robbins
Oct 1, 1987·The Journal of General Virology·H C O'Neill, M Brenan
Jun 22, 1983·Proceedings of the Royal Society of London. Series B, Containing Papers of a Biological Character·F FENNER
Oct 1, 1982·Parasitology·R M Anderson, R M May
Oct 31, 1996·Nature·A K AbbasA Sher
Jul 10, 1998·Veterinary Immunology and Immunopathology·G Karupiah

Citations

Jan 5, 2007·Nature Reviews. Microbiology·Kevin K AriënEric J Arts
Apr 29, 2011·Proceedings of the National Academy of Sciences of the United States of America·Camille BonneaudScott V Edwards
Jun 26, 2002·Viral Immunology·P J Kerr, G McFadden
Jun 21, 2003·Proceedings. Biological Sciences·S GandonAndrew F Read
Dec 5, 2012·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·Eric Vander WalFanie Pelletier
Jun 11, 2011·Veterinary Research·Bart SpiesschaertGerlinde R Van de Walle
May 2, 2008·BMC Evolutionary Biology·Gráinne H LongAndrea L Graham
Mar 2, 2010·Virology Journal·Kevin P DaltonFrancisco Parra
Jun 29, 2004·PLoS Biology·M J Mackinnon, Andrew F Read
Oct 12, 2012·PLoS Pathogens·P J KerrEdward C Holmes
Sep 16, 2009·Emerging Infectious Diseases·Frits R MooiJussi Mertsola
Jul 4, 2012·Viruses·Ingo JordanVolker Sandig
Oct 17, 2001·Developmental and Comparative Immunology·B G Magor, K E Magor
Sep 22, 2009·Archives of Virology·Fernando AldaIgnacio Doadrio
Sep 25, 2015·Immunogenetics·Ana PinheiroP J Esteves
May 7, 2013·The Veterinary Clinics of North America. Exotic Animal Practice·P J Kerr, Thomas M Donnelly
Dec 19, 2009·Veterinary Microbiology·P J KerrC K Williams
Jan 29, 2008·Veterinary Microbiology·Edita JeklovaMartin Faldyna
Sep 4, 2015·Conservation Biology : the Journal of the Society for Conservation Biology·Ella Kelly, Ben L Phillips
Nov 25, 2003·Journal of Veterinary Medicine. B, Infectious Diseases and Veterinary Public Health·I PsikalJ Bendová
May 4, 2004·Evolution; International Journal of Organic Evolution·S Gandon
Mar 30, 2006·Evolution; International Journal of Organic Evolution·Jean-Baptiste André, S Gandon
Apr 20, 2012·Molecular Ecology·Camille BonneaudGeoffrey E Hill
Dec 4, 2014·Evolutionary Applications·Eric Vander WalFanie Pelletier
Apr 20, 2007·Current Biology : CB·Mark E WickhamB Brett Finlay
Sep 6, 2008·Vaccine·M J MackinnonAndrew F Read
Oct 16, 2007·International Journal for Parasitology·I M CattadoriPeter J Hudson
Dec 3, 2014·Trends in Microbiology·Francesca Di Giallonardo, Edward C Holmes
Feb 9, 2017·Ecology Letters·Cara A FaillaceSiobain Duffy
Mar 11, 2015·Viruses·P J KerrEdward C Holmes
Feb 16, 2018·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·Tracey RussellBeata Ujvari
Aug 15, 2018·Journal of Evolutionary Biology·Daisy Elizabeth GatesMario Recker
Aug 16, 2017·Proceedings of the National Academy of Sciences of the United States of America·P J KerrAndrew F Read
Oct 29, 2018·Ecological Applications : a Publication of the Ecological Society of America·Graziella V DiRenzoKaren R Lips
Jan 31, 2014·Parasitology·Alexandre Budria, Ulrika Candolin
Feb 14, 2007·Veterinary Research·Marianne M StanfordG McFadden
Jul 12, 2019·Transboundary and Emerging Diseases·Ignacio García-BocanegraFélix Gómez-Guillamón
Oct 9, 2020·Viruses·Fábio A Abade Dos SantosMargarida D Duarte
Oct 29, 2020·Immunology and Cell Biology·Christopher C Goodnow

Related Concepts

Antibodies, Viral
Biological Evolution
Cellular Immune Response
Nongranular Leukocyte
Lung
Lymph Nodes
Myxoma virus
Myxomatosis, Infectious
Skin
Spleen

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Synthetic Genetic Array Analysis

Synthetic genetic arrays allow the systematic examination of genetic interactions. Here is the latest research focusing on synthetic genetic arrays and their analyses.

Congenital Hyperinsulinism

Congenital hyperinsulinism is caused by genetic mutations resulting in excess insulin secretion from beta cells of the pancreas. Here is the latest research.

Neural Activity: Imaging

Imaging of neural activity in vivo has developed rapidly recently with the advancement of fluorescence microscopy, including new applications using miniaturized microscopes (miniscopes). This feed follows the progress in this growing field.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Epigenetic Memory

Epigenetic memory refers to the heritable genetic changes that are not explained by the DNA sequence. Find the latest research on epigenetic memory here.

Cell Atlas of the Human Eye

Constructing a cell atlas of the human eye will require transcriptomic and histologic analysis over the lifespan. This understanding will aid in the study of development and disease. Find the latest research pertaining to the Cell Atlas of the Human Eye here.

Femoral Neoplasms

Femoral Neoplasms are bone tumors that arise in the femur. Discover the latest research on femoral neoplasms here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.