Coevolution of neuropeptidergic signaling systems: from worm to man

Annals of the New York Academy of Sciences
Tom JanssenL Schoofs

Abstract

Despite the general knowledge and repeated predictions of peptide G protein-coupled receptors following the elucidation of the Caenorhabditis elegans genome in 1998, only a few have been deorphanized so far. This was attributed to the apparent lack of coevolution between (neuro)peptides and their cognate receptors. To resolve this issue, we have used an in silico genomic data mining tool to identify the real putative peptide GPCRs in the C. elegans genome and then made a well-considered selection of orphan peptide GPCRs. To maximize our chances of a successful deorphanization, we adopted a combined reverse pharmacology approach. At this moment, we have successfully uncovered four C. elegans neuropeptide signaling systems that support the theory of receptor-ligand coevolution. All four systems are extremely well conserved within nematodes and show a high degree of similarity with their vertebrate and arthropod counterparts. Our data indicate that these four neuropeptide signaling systems have been well conserved during the course of evolution and that they were already well established prior to the divergence of protostomes and deuterostomes.

References

Feb 1, 1996·Micron : the International Research and Review Journal for Microscopy·G K Zupanc
Apr 1, 1998·Bioinformatics·T L Bailey, M Gribskov
Dec 16, 1998·Science·C I Bargmann
Mar 24, 1999·Trends in Neurosciences·D J Brownlee, I Fairweather
May 31, 2001·Genome Research·R S Hewes, P H Taghert
Aug 24, 2001·Archives of Insect Biochemistry and Physiology·J V Broeck
Nov 22, 2001·Proceedings of the National Academy of Sciences of the United States of America·A N NathooA C Hart
Feb 16, 2002·Biochemical and Biophysical Research Communications·Teresa M KubiakDavid E Lowery
Mar 21, 2002·Proceedings of the National Academy of Sciences of the United States of America·Frank StaubliCornelis J P Grimmelikhuijzen
Oct 9, 2002·Current Opinion in Neurobiology·Janet E Richmond, Kendal S Broadie
Dec 3, 2002·Biochemical and Biophysical Research Communications·Annette IversenCornelis J P Grimmelikhuijzen
Aug 15, 2003·Journal of Cell Science·Robby M Weimer, Erik M Jorgensen
Jun 1, 2004·Pharmacological Reviews·Paul J BrightonGary B Willars
Nov 16, 2004·Nature Genetics·John ParkinsonMark L Blaxter
Feb 1, 2005·Trends in Pharmacological Sciences·Timothy G Geary, Teresa M Kubiak
Feb 3, 2005·Molecular Pharmacology·Robert Fredriksson, Helgi B Schiöth
Mar 12, 2005·Proceedings of the National Academy of Sciences of the United States of America·James H ThomasWillie J Swanson
Apr 6, 2005·Biochemical and Biophysical Research Communications·Inge MertensLiliane Schoofs
Aug 2, 2005·Biochemical and Biophysical Research Communications·Giuseppe CazzamaliCornelis J P Grimmelikhuijzen
Feb 3, 2006·Protein Science : a Publication of the Protein Society·Markus WistrandErik L L Sonnhammer
Mar 4, 2006·The Neuroscientist : a Review Journal Bringing Neurobiology, Neurology and Psychiatry·Bethe A Scalettar
Apr 8, 2006·International Journal for Parasitology·Paul McVeighAaron G Maule
Jul 4, 2006·Physiological Reviews·Marlène DufresneDaniel Fourmy
Jul 11, 2006·Trends in Parasitology·Paul McVeighAaron G Maule
Sep 5, 2006·Cellular and Molecular Life Sciences : CMLS·R Predel, C Wegener
Dec 1, 2006·BMC Evolutionary Biology·Sivan Vadakkadath MeethalCraig S Atwood
Mar 27, 2007·Progress in Neurobiology·Steven J HussonLiliane Schoofs
Jun 19, 2007·General and Comparative Endocrinology·Andrew M VoskoChristopher S Colwell
Aug 22, 2007·Biochemical and Biophysical Research Communications·Stine S OlsenFrank Hauser
Dec 1, 2007·WormBook : the Online Review of C. Elegans Biology·Hugh M Robertson, James H Thomas
Dec 1, 2007·WormBook : the Online Review of C. Elegans Biology·Daniel L Chase, Michael R Koelle

❮ Previous
Next ❯

Citations

May 15, 2013·Proceedings of the National Academy of Sciences of the United States of America·Olivier Mirabeau, Jean-Stéphane Joly
May 3, 2013·Proceedings of the National Academy of Sciences of the United States of America·Gáspár Jékely
Oct 12, 2012·Genetics·Gregory MinevichOliver Hobert
May 27, 2014·General and Comparative Endocrinology·Ravisankar Valsalan, Narayanan Manoj
Jun 1, 2014·Current Opinion in Neurobiology·Paul S Katz, Joshua L Lillvis
Dec 1, 2012·International Journal for Parasitology. Drugs and Drug Resistance·Paul McVeighAaron G Maule
Jul 21, 2015·Cell Reports·Philipp Bauknecht, Gáspár Jékely
May 15, 2012·Molecular and Cellular Endocrinology·Ellen MeelkopLiliane Schoofs
Jul 20, 2014·Molecular and Biochemical Parasitology·Ross C AndersonArieh A Katz
Oct 30, 2014·Frontiers in Endocrinology·Chris Li, Kyuhyung Kim
Aug 16, 2018·BMC Genomics·Anna Grandchamp, Philippe Monget
Feb 8, 2019·Frontiers in Neural Circuits·Erik SvenssonHelgi B Schiöth
Jul 3, 2017·Physiology & Behavior·Gary R Ten Eyck, Lily M Ten Eyck
Sep 17, 2021·Journal of Neurochemistry·Aelon Rahmani, Yee Lian Chew

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.