Coevolution pays off: Herpesviruses have the license to escape the DNA sensing pathway

Medical Microbiology and Immunology
Markus StempelMelanie M Brinkmann

Abstract

Early detection of viral invasion by pattern recognition receptors (PRR) is crucial for the induction of a rapid and efficient immune response. Cytosolic DNA sensors are the most recently described class of PRR, and induce transcription of type I interferons (IFN) and proinflammatory cytokines via the key adaptor protein stimulator of interferon genes (STING). Herpesviruses are a family of large DNA viruses widely known for their immense arsenal of proteins dedicated to manipulating and evading host immune responses. Tantamount to the significant role played by DNA sensors and STING in innate immune responses, herpesviruses have in turn evolved a range of mechanisms targeting virtually every step of this key signaling pathway. Strikingly, some herpesviruses also take advantage of this pathway to promote their own replication. In this review, we will summarize the current understanding of DNA sensing and subsequent induction of signaling and transcription, and showcase the close adaptation of herpesviruses to their host reflected by the myriad of viral proteins dedicated to modulating this critical innate immune pathway.

References

Mar 29, 2001·The New England Journal of Medicine·M VázquezE D Shapiro
May 22, 2002·Nature Immunology·Astrid KrmpotićStipan Jonjić
Sep 16, 2003·Proceedings of the National Academy of Sciences of the United States of America·Edward P Browne, Thomas Shenk
Mar 3, 2004·Proceedings of the National Academy of Sciences of the United States of America·Audrey EsclatineBernard Roizman
Feb 15, 2005·Journal of Virology·Jessica M BonamePhilip G Stevenson
Mar 3, 2007·Cancer Research·Henrik HjalgrimMads Melbye
Nov 28, 2007·Annual Review of Pathology·J L Kutok, F Wang
Dec 11, 2008·Archives of Virology·Andrew J DavisonEtienne Thiry
May 13, 2009·Proceedings of the National Academy of Sciences of the United States of America·Wenxiang SunZhengfan Jiang
Nov 21, 2009·Proceedings of the National Academy of Sciences of the United States of America·Tatsuya SaitohShizuo Akira
Jan 6, 2010·Antimicrobial Agents and Chemotherapy·Peter LischkaHolger Zimmermann
Oct 5, 2010·Nature Immunology·Leonie UnterholznerAndrew G Bowie
Dec 17, 2010·Cellular and Molecular Life Sciences : CMLS·Hiroki Ishikawa, Glen N Barber
Jan 12, 2011·Annual Review of Immunology·Erik BartonSamuel H Speck
Mar 15, 2011·The Journal of Immunology : Official Journal of the American Association of Immunologists·Xing ZhangTomozumi Imamichi
Mar 8, 2012·Science Signaling·Yasuo Tanaka, Zhijian J Chen

❮ Previous
Next ❯

Citations

Oct 20, 2019·Vaccines·Mario Alberto Ynga-DurandLuka Cicin-Sain
Dec 11, 2019·Nature Immunology·Andrea Ablasser, Sun Hur
Sep 11, 2019·Journal of Clinical Medicine·Florian Full, Armin Ensser
Dec 19, 2019·Frontiers in Microbiology·Yingying Lin, Chunfu Zheng
May 1, 2020·Frontiers in Microbiology·Valentina Dell'OsteMarco De Andrea
Jul 28, 2020·Proceedings of the National Academy of Sciences of the United States of America·Carina ElsnerChristine Goffinet
Apr 1, 2020·Frontiers in Cellular and Infection Microbiology·Robert F Kalejta, Emily R Albright
Mar 3, 2020·Frontiers in Microbiology·A Cristina Gonzalez-PerezMelanie M Brinkmann
Jan 10, 2021·International Journal of Molecular Sciences·Guendalina FroechlichNicola Zambrano
Nov 7, 2020·EMBO Reports·Jonny Hertzog, Jan Rehwinkel
Jun 3, 2021·Viruses·Miroslava ŠudomováSherif T S Hassan
Jun 26, 2021·Proceedings of the National Academy of Sciences of the United States of America·Yongzhi ChenKatherine A Fitzgerald
Sep 1, 2021·Current Opinion in Virology·Katinka DöhnerBeate Sodeik
Sep 30, 2021·Annual Review of Virology·Yiping WangLaurie T Krug
Oct 9, 2021·Clinical Science·Laura MarongiuFrancesca Granucci

❮ Previous
Next ❯

Methods Mentioned

BETA
pulldown
ELISA
Y2H
Co-IP
nuclear translocation
ubiquitination
electrophoretic mobility shift assay
Co-IPs
transfection

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

© 2022 Meta ULC. All rights reserved