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Coevolutionary analyses require phylogenetically deep alignments and better null models to accurately detect inter-protein contacts within and between species

bioRxiv

Feb 6, 2015

Aram Avila-Herrera, Katherine S. Pollard

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Abstract

When biomolecules physically interact, natural selection operates on them jointly. Contacting positions in protein and RNA structures exhibit correlated patterns of sequence evolution due to constraints imposed by the interaction, and molecular arms races can develop between interacting...read more

Mentioned in this Paper

Species
Virus by host
Evaluation
Racial Group
RNA
Protein complex
Bacterial Proteins
Structure
Protein-Protein Interaction
Depth
7
1
20
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  • Coevolutionary analyses require phylogenetically deep alignments and better null models to accurately detect inter-protein contacts within and between species

    bioRxiv

    Feb 6, 2015

    Aram Avila-Herrera, Katherine S. Pollard

    PMID: 990014902

    DOI: 10.1101/014902

    Abstract

    When biomolecules physically interact, natural selection operates on them jointly. Contacting positions in protein and RNA structures exhibit correlated patterns of sequence evolution due to constraints imposed by the interaction, and molecular arms races can develop between interacting...read more

    Mentioned in this Paper

    Species
    Virus by host
    Evaluation
    Racial Group
    RNA
    7
    1
    20

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