Coexistence of Creutzfeldt-Jakob disease, Lewy body disease, and Alzheimer's disease pathology: an autopsy case showing typical clinical features of Creutzfeldt-Jakob disease

Neuropathology : Official Journal of the Japanese Society of Neuropathology
Takashi HaraguchiShigetoshi Kuroda

Abstract

We report here an autopsy case of sporadic Creutzfeldt-Jakob disease (CJD) without hereditary burden and with a clinical course typical of sporadic CJD. A 77-year old man developed memory disturbance, followed by gait disturbance and myoclonus. He died of bronchopneumonia 5 months after the disease onset. Post-mortem examination revealed neuronal loss, astrocytosis, and patchy spongiosis in the cerebral cortex and lenticular nuclei. Synaptic-type deposits of prion protein were present in the cerebral cortex. Additionally, Lewy bodies were observed in the cerebral cortex and substantia nigra. Furthermore, senile plaques compatible with definite Alzheimer's disease according to Consortium to Establish a Registry for Alzheimer's disease criteria and neurofibrillary changes of the limbic system consistent with Braak stage IV were found. Based on a review of the published literature, this autopsy case is very rare, and we suppose that the incidence of CJD accompanied by Lewy body disease and Alzheimer's disease is very low.

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Citations

Aug 26, 2009·Neuropathology : Official Journal of the Japanese Society of Neuropathology·Hidenori YoshidaShigetoshi Kuroda
Apr 2, 2010·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Rodrigo MoralesClaudio Soto
Nov 26, 2010·Expert Review of Vaccines·Thomas Wisniewski, Fernando Goñi
Mar 19, 2011·Annals of Neurology·Suman JayadevJames B Leverenz
Apr 18, 2014·Clinical Anatomy : Official Journal of the American Association of Clinical Anatomists & the British Association of Clinical Anatomists·Barry M BradfordNeil A Mabbott
Jan 31, 2014·Journal of Neurology·Agnès JacquinFlorence Pasquier
Mar 9, 2018·Dementia and Geriatric Cognitive Disorders Extra·Tomaž RusMilica G Kramberger
Feb 13, 2018·Molecular Neurobiology·Anna Villar-PiquéInga Zerr
Nov 14, 2018·Movement Disorders : Official Journal of the Movement Disorder Society·Inês Caldeira BrásTiago Fleming Outeiro
May 6, 2020·Neuropathology : Official Journal of the Japanese Society of Neuropathology·Akio AkagiMari Yoshida
Sep 20, 2017·Journal of Neuropathology and Experimental Neurology·Hiroyuki HondaToru Iwaki

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