Coexistence of five G6PD variants indicates ethnic complexity of Phuket islanders, Southern Thailand

Journal of Human Genetics
Aya NinokataTakafumi Ishida

Abstract

Glucose-6-phosphate dehydrogenase (G6PD) deficiency is the most common enzymopathy in humans. The prevalence of G6PD deficiency and its molecular basis were studied in Phuket islanders, Southern Thailand. A total of 345 volunteers (123 males and 222 females) were recruited in this study. Infection with Plasmodium falciparum or Plasmodium vivax was not detected in any of these subjects by polymerase chain reaction (PCR)-based diagnosis. G6PD-deficient individuals were identified with the WST-8/1-methoxy PMS method. The molecular basis of G6PD deficiency was investigated by PCR-direct sequencing procedures or PCR-restriction enzyme fragment length polymorphism assays. The numbers of individuals showing severe and mild G6PD deficiency were 14 and 21, respectively. A high prevalence of G6PD deficiency was observed in subjects with Moken (15.4%) or Thai (15.5%) ethnic background. G6PD Mahidol (487G>A) (n=14), G6PD Viangchan (871G>A) (n=11), G6PD Gaohe (95A>G) (n=2), G6PD Kaiping (1388G>A) (n=1), and G6PD Kerala-Kalyan (949G>A) (n=1) were identified. The results suggest that several groups of people of the Asian Continent, such as Burmese, Laotian or Cambodian, Thai and Chinese, participated in the establishment of the ethnic identit...Continue Reading

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Citations

Dec 11, 2007·Human Molecular Genetics·Akihiro FujimotoKatsushi Tokunaga
Mar 20, 2010·Clinical Genetics·M Faiyaz-Ul-HaqueJ A K M Bhuiyan
Nov 30, 2007·Journal of Human Genetics·Issarang NuchprayoonWarisa Charoenvej
Jan 23, 2009·Journal of Human Genetics·Kelsey Needham DancauseJ Koji Lum
Feb 24, 2009·Blood Cells, Molecules & Diseases·Ella T NkhomaErnest Beutler
Nov 15, 2021·British Journal of Haematology·John ChapinAlexis A Thompson

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