Coexistence of herpes simplex virus infection in microsporidial stromal keratitis associated with granulomatous inflammation

Indian Journal of Ophthalmology
Ruchi MittalSavitri Sharma

Abstract

Microsporidial stromal keratitis poses several diagnostic challenges. Patients may present with corneal ulceration, marked stromal thinning, or even as a quite corneal scar. The presentation of microsporidial stromal keratitis commonly mimics viral keratitis. Microbiology scrapings are usually helpful; however, scraping and culture-negative cases pose a significant diagnostic dilemma. Histopathological examination is diagnostic but shows varying degree of inflammation, predominantly composed of polymorphonuclear leukocytes. Granulomatous inflammation, in microsporidial stromal keratitis, is never well described, and the authors in this article aim to describe the presence of granulomatous inflammation in microsporidial stromal keratitis, in patients with associated herpes simplex virus (HSV) keratitis. This was a retrospective and observational study conducted at a tertiary eye care center. Of 263 patients who underwent therapeutic penetrating keratoplasty for infectious keratitis, during 2011-2013, seven patients were diagnosed as microsporidial stromal keratitis. Microsporidial spores could be demonstrated on microbiological scrapings in 5/7 (71%) of cases, but identified on histopathological examination and also confirmed on...Continue Reading

References

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Citations

Apr 26, 2018·The American Journal of Tropical Medicine and Hygiene·Jordan LeroyBoualem Sendid
Sep 10, 2020·BMJ Case Reports·Anirban DuttaSmruti Rekha Priyadarshini
Aug 23, 2021·The Ocular Surface·Amrita MohantyMeena Lakhmipathy
Sep 1, 2021·Ocular Immunology and Inflammation·Richa DhamanGeetha Iyer

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Methods Mentioned

BETA
scraping
scrapings
PCR

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