Coexistence of immune-mediated diseases in sarcoidosis. Frequency and clinical significance in 1737 patients.

Joint, Bone, Spine : Revue Du Rhumatisme
Pilar Brito-ZerónSarcoGEAS-SEMI Registry

Abstract

To analyze whether immune-mediated diseases (IMDs) occurs in sarcoidosis more commonly than expected in the general population, and how concomitant IMDs influence the clinical presentation of the disease. We searched for coexisting IMDs in patients included in the SARCOGEAS-cohort, a multicenter nationwide database of consecutive patients diagnosed according to the ATS/ESC/WASOG criteria. Comparisons were made considering the presence or absence of IMD clustering, and odds ratios (OR) and their 95% confidence intervals (CI) were calculated as the ratio of observed cases of every IMD in the sarcoidosis cohort to the observed cases in the general population. Among 1737 patients with sarcoidosis, 283 (16%) patients presented at least one associated IMD. These patients were more commonly female (OR: 1.98, 95% CI: 1.49-2.62) and were diagnosed with sarcoidosis at an older age (49.6 vs. 47.5years, P<0.05). The frequency of IMDs in patients with sarcoidosis was nearly 2-fold higher than the frequency observed in the general population (OR: 1.64, 95% CI: 1.44-1.86). Significant associations were identified in 17 individual IMDs. In comparison with the general population, the IMDs with the strongest strength of association with sarcoido...Continue Reading

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Citations

Jul 15, 2021·Current Opinion in Pulmonary Medicine·Minhyuk SongNadera J Sweiss
Oct 16, 2021·Joint, Bone, Spine : Revue Du Rhumatisme·Ramón MazzucchelliAlberto García Vadillo

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