Abstract
Lupus erythematosus (LE) and porphyria cutanea tarda (PCT) may have similar clinical presentations, and their coexistence presents special problems in diagnosis and management. The purposes of this study were to describe a patient with discoid LE and PCT and to present a review of 15 patients with coexistent LE (all variants) and PCT. The medical records of all patients with coexistent LE and PCT seen between 1976 and 1995 were retrospectively reviewed. Of 6179 cases of LE and 676 cases of porphyria (all variants), there were 15 patients, 6 men and 9 women, with coexistent LE and PCT. The mean age at diagnosis of LE was 42.8 years and of PCT was 48 years. Nine patients had discoid LE; five patients had systemic LE, and one patient had subacute cutaneous LE. The initial diagnosis was LE in eight patients, PCT in five patients, and simultaneous LE and PCT in two patients. Precipitating factors for PCT included alcohol in seven patients, iron overload in one patient, and estrogen in one patient. Treatment of LE with hydroxychloroquine 200 mg daily precipitated PCT in two patients. Patients were treated with phlebotomy or low-dose antimalarials for PCT. Patients with systemic LE received systemic glucocorticoid therapy. Patients wi...Continue Reading
References
Apr 1, 1990·Annals of the Rheumatic Diseases·S A AllardJ T Scott
Jun 1, 1989·British Journal of Rheumatology·S A Allard, J T Scott
Jan 1, 1989·Archives of Dermatological Research·D GrisoG Topi
Sep 1, 1972·The British Journal of Dermatology·J J TaljaardS M Joubert
Aug 1, 1970·Archives of Dermatology·A N Domonkos
Sep 1, 1982·Quaderni Sclavo di diagnostica clinica e di laboratorio·A AmanteaG Topi
Jan 1, 1982·The Journal of Clinical Investigation·G VarigosD R Bickers
Mar 1, 1982·Archives of Dermatology·O Clemmensen, K Thomsen
Sep 1, 1981·Journal of the American Academy of Dermatology·J P Callen, L Ross
May 1, 1996·Mammalian Genome : Official Journal of the International Mammalian Genome Society·C WuR J Desnick
Dec 1, 1996·Archives of Dermatology·W J O'ConnorL Barnes
Feb 15, 1997·The Journal of Clinical Investigation·B P TsaoJ I Rotter
May 1, 1957·The American Journal of Medicine·J WALDENSTROM
Jun 1, 1957·A.M.A. Archives of Dermatology·M J DAVIS, D E V PLOEG
Jun 1, 1959·The British Journal of Dermatology·C W MARSDEN
Aug 25, 1960·The New England Journal of Medicine·R SCHMID
Citations
Nov 26, 1999·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·C AliouaA A Bakir
Jul 2, 2009·Mayo Clinic Proceedings·Aditya BardiaKris G Thomas
Dec 6, 2007·International Journal of Dermatology·Anne-Moon van Tuyll van SerooskerkenJorge Frank
May 3, 2006·International Journal of Dermatology·Junko MurataHiroshi Shimizu
Jul 24, 2014·Anais Brasileiros De Dermatologia·Su FangTieNan Li
Jan 14, 2005·Lupus·W TingR D Sontheimer
Nov 11, 1999·Rheumatology·A SinhaJ M Sowden
Mar 14, 2000·Lupus·T P MillardJ M McGregor
Apr 11, 2018·Lupus·B SunkaraW J McCune
Mar 7, 2007·Journal der Deutschen Dermatologischen Gesellschaft = Journal of the German Society of Dermatology : JDDG·Wiebke K PeitschSergij Goerdt
Jul 16, 2014·World Journal of Hepatology·Fernando BessoneMarcelo G Roma
Dec 22, 1999·Seminars in Cutaneous Medicine and Surgery·H W Lim, J L Cohen
Dec 6, 2000·The Australasian Journal of Dermatology·N R Bleasel, G A Varigos
Mar 26, 2011·Anais Brasileiros De Dermatologia·Leticia HaendchenThelma L Skare