Coexistence of malignant struma ovarii and Graves' disease.

Endocrine Practice : Official Journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists
Sherry K SussmanAlan Heimann

Abstract

To report an unusual case of hyperthyroidism from Graves' disease that was coexistent with malignant struma ovarii. We summarize the clinical history, physical findings, laboratory data, imaging studies, pathologic features, and treatment in a patient with recurrent hyperthyroidism and discuss the incidence of ovarian tumors of various histologic origins, including thyroid tissue (that is, struma ovarii). Five years after diagnosis of Graves' disease and resolution of symptoms with 1 year of antithyroid drug therapy, a 53-year-old woman had recurrence of palpitations, tremors, and weight loss. Results of thyroid function tests showed high total and free thyroxine levels and a low thyrotropin level. Thyroid radioiodine uptake was high (69% at 24 hours). Abdominal ultrasound studies disclosed a cystic mass in the right adnexal area. Total abdominal hysterectomy and bilateral oophorectomy revealed a 7.5-cm cystic right ovary that contained a 1.0-cm struma ovarii with a 0.4-cm nodule of follicular variant papillary thyroid carcinoma within it. The patient was treated with methimazole and radioiodine ablation of the thyroid. Three months later, a massive myocardial infarction resulted in her death. The concomitant presence of Graves...Continue Reading

References

Jul 1, 1992·Clinical Nuclear Medicine·R D Thomas, V B Batty
Apr 1, 1990·The Journal of Clinical Endocrinology and Metabolism·E L Mazzaferri
May 1, 1990·The British Journal of Radiology·M E O'ConnellC L Harmer
Feb 1, 1989·Gynecologic Oncology·N G RosenblumJ J Mikuta
Jan 15, 1983·Cancer·F J Pardo-Mindan, J J Vazquez
Aug 1, 1993·International Journal of Gynaecology and Obstetrics : the Official Organ of the International Federation of Gynaecology and Obstetrics·A AyhanS Ruacan
Oct 1, 1993·International Journal of Gynecological Pathology : Official Journal of the International Society of Gynecological Pathologists·K DevaneyF A Tavassoli
Jan 1, 1996·European Journal of Nuclear Medicine·W BrennerE Henze
Dec 1, 1995·Thyroid : Official Journal of the American Thyroid Association·M R Bayot, I J Chopra
Jan 1, 1997·Gynecologic and Obstetric Investigation·V BerghellaR E Zuna
Jun 15, 1999·Gynecologic Oncology·R B DardikF J Montz
Jun 26, 2001·Endocrine Practice : Official Journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists·I Sachmechi, R Bitton
Dec 1, 1946·Archives of Surgery·F C SMITH

❮ Previous
Next ❯

Citations

Aug 30, 2008·International Journal of Gynecological Pathology : Official Journal of the International Society of Gynecological Pathologists·Lawrence M RothAleksander Talerman
Mar 1, 2012·Journal of Obstetrics and Gynaecology : the Journal of the Institute of Obstetrics and Gynaecology·S JeanC S Chu
Jun 29, 2013·Metabolism: Clinical and Experimental·Athanasios D AnastasilakisStergios Papachatzopoulos
Sep 30, 2006·Pathology·Lydia Ng, Barbara Brennan
Nov 7, 2014·Thyroid : Official Journal of the American Thyroid Association·Paolo GoffredoJulie Ann Sosa
May 26, 2011·Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology·Isabella LupiEnrico Macchia
Nov 5, 2019·Archives of Gynecology and Obstetrics·Molly R SiegelBiftu M Mengesha
Nov 5, 2015·BMC Endocrine Disorders·Tullaya SitasuwanNuntakorn Thongtang
Jun 30, 2007·Endocrine Practice : Official Journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists·Maria G ChiofaloLuciano Pezzullo
Aug 14, 2021·Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology·Agnieszka PodfigurnaBlazej Meczekalski
Jul 6, 2021·The Journal of Obstetrics and Gynaecology Research·Sevgi AyhanGunsu Kimyon Comert

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Endocrine Practice : Official Journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists
Maria G ChiofaloLuciano Pezzullo
Clinical Nuclear Medicine
P J Grandet, M H Remi
© 2022 Meta ULC. All rights reserved