Abstract
The aim of the present study was to clarify the underlying molecules that might contribute to the highly aggressive behavior of anaplastic thyroid carcinoma. We selected 5 cases of anaplastic thyroid carcinoma that had a differentiated area to determine differences in the molecules of undifferentiated and differentiated cancer cells. We immunohistochemically examined the localization of nuclear antigen (Ki-67), proliferating cell nuclear antigen (PCNA), p53, apoptotic protease-activating factor-1 (Apaf-1), CD26, galectin-3, E-cadherin, and CD147. We found increased Ki-67, PCNA, and p53 labeling indices; decreased levels of Apaf-1, CD26, galectin-3, and E-cadherin; and overexpression of CD147 in the undifferentiated area compared with the differentiated area. These findings indicate high proliferative properties, suppression of apoptosis, disruption of cell-cell interaction, and induction of matrix metalloproteinases in the undifferentiated areas. Thus the molecules examined might be useful for evaluating the aggressive nature of this tumor and the prognosis.
Citations
May 3, 2014·Endocrine-related Cancer·Zhenying GuoRicardo V Lloyd
Feb 26, 2013·Endocrine Pathology·Ricardo V LloydKalman Kovacs
Oct 20, 2012·European Journal of Nuclear Medicine and Molecular Imaging·Chien-Chih KeOscar K Lee
Jun 13, 2012·Cancer Biology & Therapy·Juanita J EvansDavid Goldenberg
Feb 12, 2017·Bulletin du cancer·Asma FouratiAhmed El May
Jun 27, 2008·Endocrine Pathology·Hüseyin K TürközDeniz Ozcan
Oct 30, 2009·Cytopathology : Official Journal of the British Society for Clinical Cytology·Y AratakeE Ohno
Nov 6, 2009·Annales de pathologie·Bernard Caillou, Gabriel Malouf
Sep 2, 2014·International Journal of Cancer. Journal International Du Cancer·Bing ZhengHui Lu
Jan 28, 2012·Thyroid : Official Journal of the American Thyroid Association·Yoko OmiMakio Kobayashi
Feb 26, 2013·Thyroid : Official Journal of the American Thyroid Association·Kazuaki YasuiYuji Nagayama
Apr 24, 2010·Virchows Archiv : an International Journal of Pathology·Juliette Hommell-FontaineMyriam Decaussin-Petrucci
Oct 29, 2018·Histopathology·Jianghua WuBaocun Sun
Aug 18, 2012·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Darya BuehlerRicardo V Lloyd
Jan 16, 2014·Oncology Reports·Yong-Ju GaoJian-Kui Han