PMID: 16613343Apr 15, 2006Paper

Coexistent anaplastic and differentiated thyroid carcinoma: an immunohistochemical study

American Journal of Clinical Pathology
Yatsuki AratakeKazuo Tamura

Abstract

The aim of the present study was to clarify the underlying molecules that might contribute to the highly aggressive behavior of anaplastic thyroid carcinoma. We selected 5 cases of anaplastic thyroid carcinoma that had a differentiated area to determine differences in the molecules of undifferentiated and differentiated cancer cells. We immunohistochemically examined the localization of nuclear antigen (Ki-67), proliferating cell nuclear antigen (PCNA), p53, apoptotic protease-activating factor-1 (Apaf-1), CD26, galectin-3, E-cadherin, and CD147. We found increased Ki-67, PCNA, and p53 labeling indices; decreased levels of Apaf-1, CD26, galectin-3, and E-cadherin; and overexpression of CD147 in the undifferentiated area compared with the differentiated area. These findings indicate high proliferative properties, suppression of apoptosis, disruption of cell-cell interaction, and induction of matrix metalloproteinases in the undifferentiated areas. Thus the molecules examined might be useful for evaluating the aggressive nature of this tumor and the prognosis.

Citations

May 3, 2014·Endocrine-related Cancer·Zhenying GuoRicardo V Lloyd
Feb 26, 2013·Endocrine Pathology·Ricardo V LloydKalman Kovacs
Oct 20, 2012·European Journal of Nuclear Medicine and Molecular Imaging·Chien-Chih KeOscar K Lee
Jun 27, 2008·Endocrine Pathology·Hüseyin K TürközDeniz Ozcan
Oct 30, 2009·Cytopathology : Official Journal of the British Society for Clinical Cytology·Y AratakeE Ohno
Nov 6, 2009·Annales de pathologie·Bernard Caillou, Gabriel Malouf
Sep 2, 2014·International Journal of Cancer. Journal International Du Cancer·Bing ZhengHui Lu
Jan 28, 2012·Thyroid : Official Journal of the American Thyroid Association·Yoko OmiMakio Kobayashi
Feb 26, 2013·Thyroid : Official Journal of the American Thyroid Association·Kazuaki YasuiYuji Nagayama
Apr 24, 2010·Virchows Archiv : an International Journal of Pathology·Juliette Hommell-FontaineMyriam Decaussin-Petrucci
Aug 18, 2012·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Darya BuehlerRicardo V Lloyd

❮ Previous
Next ❯

Related Concepts

Related Feeds

Apoptosis

Apoptosis is a specific process that leads to programmed cell death through the activation of an evolutionary conserved intracellular pathway leading to pathognomic cellular changes distinct from cellular necrosis

Apoptosis in Cancer

Apoptosis is an important mechanism in cancer. By evading apoptosis, tumors can continue to grow without regulation and metastasize systemically. Many therapies are evaluating the use of pro-apoptotic activation to eliminate cancer growth. Here is the latest research on apoptosis in cancer.

Cadherins and Catenins

Cadherins (named for "calcium-dependent adhesion") are a type of cell adhesion molecule (CAM) that is important in the formation of adherens junctions to bind cells with each other. Catenins are a family of proteins found in complexes with cadherin cell adhesion molecules of animal cells: alpha-catenin can bind to β-catenin and can also bind actin. β-catenin binds the cytoplasmic domain of some cadherins. Discover the latest research on cadherins and catenins here.