Coexisting dementia and depression in Parkinson's disease.

Archives of Neurology
M SanoR Mayeux

Abstract

Dementia and depression in patients with Parkinson's disease have been reported separately, but their prevalence is controversial. This study examines the coexistence of these two problems and suggests a common underlying biochemical system. We examined these two entities by retrospective chart review and cerebrospinal fluid biochemistry. We found a prevalence of 10.9% for dementia, 51% for depression, and 5.4% for coincident depression and dementia. In a prospective study of patients with Parkinson's disease we found a continuum of cerebrospinal fluid 5-hydroxyindoleacetic acid concentrations. Patients who were either depressed or demented had lower concentrations of this metabolite than other patients with Parkinson's disease, but patients who were depressed and demented had the lowest levels. These results suggest that the coexistence of dementia and depression represents a unique clinical entity in Parkinson's disease. The serotonergic system may be involved in depression and dementia because evidence of a cumulative effect on this biochemical system is present.

Citations

May 1, 1992·Journal of Neurology, Neurosurgery, and Psychiatry·S E StarksteinR G Robinson
Mar 7, 1998·Journal of Neurology, Neurosurgery, and Psychiatry·F MahieuxF Boller
Apr 20, 2007·Journal of Neurology, Neurosurgery, and Psychiatry·D VerbaanJ J van Hilten
Apr 11, 2003·Current Psychiatry Reports·Laura Marsh, Ariel Berk
Jun 5, 2002·Current Neurology and Neuroscience Reports·Oksana Suchowersky
Jul 27, 2001·Journal of Chemical Neuroanatomy·Y SmithA I Levey
Nov 1, 1994·Italian Journal of Neurological Sciences·P SoliveriF Girotti
Sep 1, 1990·Neuropsychology Review·S A RaskinJ Tweedy
May 1, 1993·The International Journal of Neuroscience·R Sandyk
Sep 1, 1992·The International Journal of Neuroscience·R Sandyk, G L Willis
Aug 25, 2007·Annual Review of Clinical Psychology·Philip D HarveyChristopher R Bowie
Feb 9, 2000·Psychosomatics·L Marsh
Nov 1, 1996·The Journal of Psychology·J B Murray
Mar 9, 2017·Bulletin of the Menninger Clinic·Muhammad Adnan KhanHassaan Tohid
Oct 7, 2004·Parkinsonism & Related Disorders·T A ZesiewiczK L Sullivan
Jul 26, 2000·The American Journal of Geriatric Psychiatry : Official Journal of the American Association for Geriatric Psychiatry·K A LockwoodW G Van Gorp
May 12, 2009·Journal of Geriatric Psychiatry and Neurology·Hubert H FernandezMichael S Okun
Sep 30, 2017·Archives of Clinical Neuropsychology : the Official Journal of the National Academy of Neuropsychologists·Julie A Fields
Feb 7, 2003·International Journal of Geriatric Psychiatry·D P DevanandHarold A Sackeim
Nov 30, 2006·International Journal of Geriatric Psychiatry·Peijun ChenAlan M Mellow
Jan 1, 1994·Movement Disorders : Official Journal of the Movement Disorder Society·P Martínez-MartínF Bermejo
Sep 1, 1990·Postgraduate Medical Journal·K Granville-Grossman

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