Coexisting hyperthyroidism and primary hyperparathyroidism with vitamin D-deficient osteomalacia in a Vietnamese immigrant.

Endocrine Practice : Official Journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists
K V Luong, L T Nguyen

Abstract

To present the first report of concurrent hyperthyroidism, primary hyperparathyroidism (PHP), and vitamin D-deficient osteomalacia. We describe the complicated clinical course in a 65-year-old Vietnamese immigrant, and underlying factors potentially contributing to her condition are discussed. Our patient, who had hyperthyroidism and hypercalcemia, was found to have an inappropriately high level of intact parathyroid hormone (PTH) because of a parathyroid adenoma, detected on a parathyroid scan. With propranolol treatment, however, improvement was noted in both laboratory data--intact PTH, ionized calcium, serum total calcium, 1,25-dihydroxyvitamin D3 [1,25(OH)2D3], and urinary cyclic adenosine monophosphate--and findings on ultrasonography and nuclear parathyroid scanning. Later, the adenoma was removed surgically. The improvement of PHP after administration of a beta-adrenergic blocker suggested that the parathyroid adenoma in this patient was not completely autonomous. The patient also had vitamin D-deficient osteomalacia that was confirmed by a low serum level of 25-hydroxyvitamin D3 (25OHD3) and by bone histomorphometry. This coexisting condition was caused by the long-term increase in conversion of 25OHD3 to 1,25(OH)2D3 f...Continue Reading

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Citations

Dec 21, 2004·Journal of Internal Medicine·J P BilezikianS J Silverberg
Jun 27, 2013·Nutrition Journal·Khanh vinh quốc Lu'o'ng, Lan Thi Hoàng Nguyễn
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Sep 24, 2013·Therapeutic Advances in Respiratory Disease·Khanh Vinh Quoc Luong, Lan Thi Hoàng Nguyen
Dec 29, 2011·American Journal of Alzheimer's Disease and Other Dementias·Khanh Vinh Quôc Lu'o'ng, Lan Thi Hoàng Nguyên
Jan 17, 2013·American Journal of Alzheimer's Disease and Other Dementias·Khanh Vinh Quoc Lu'o'ng, Lan Thi Hoàng Nguyen
Aug 30, 2012·Journal of Neuroscience Research·Khanh Vinh Quôc Luong, Lan Thi Hoàng Nguyên

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