Coexpression analysis of nine neuropeptides in the neurosecretory preoptic area of larval zebrafish

Frontiers in Neuroanatomy
Ulrich Herget, Soojin Ryu

Abstract

The paraventricular nucleus (PVN) of the hypothalamus in mammals coordinates neuroendocrine, autonomic and behavioral responses pivotal for homeostasis and the stress response. A large amount of studies in rodents has documented that the PVN contains diverse neuronal cell types which can be identified by the expression of distinct secretory neuropeptides. Interestingly, PVN cell types often coexpress multiple neuropeptides whose relative coexpression levels are subject to environment-induced plasticity. Due to their small size and transparency, zebrafish larvae offer the possibility to comprehensively study the development and plasticity of the PVN in large groups of intact animals, yet important anatomical information about the larval zebrafish PVN-homologous region has been missing. Therefore we recently defined the location and borders of the larval neurosecretory preoptic area (NPO) as the PVN-homologous region in larval zebrafish based on transcription factor expression and cell type clustering. To identify distinct cell types present in the larval NPO, we also generated a comprehensive 3D map of 9 zebrafish homologs of typical neuropeptides found in the mammalian PVN (arginine vasopressin (AVP), corticotropin-releasing ho...Continue Reading

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Citations

Jun 15, 2016·Developmental and Comparative Immunology·B M Lidy Verburg-van KemenadeMagdalena Chadzinska
Feb 23, 2018·Journal of Molecular Endocrinology·José Luis SoengasMaría Jesús Delgado
Dec 5, 2017·ELife·Elizabeth A WilliamsGáspár Jékely
Mar 1, 2019·Scientific Reports·Héctor Carreño GutiérrezWilliam H J Norton
Aug 16, 2018·Cell and Tissue Research·Jatin NagpalSoojin Ryu
Dec 10, 2016·Frontiers in Neuroanatomy·Gabriel N Santos-DuránEva Candal
Apr 3, 2018·Nature Biotechnology·Bushra RajAlexander F Schier
Jun 24, 2020·Nature Neuroscience·Matthew Lovett-BarronKarl Deisseroth
Sep 19, 2020·Scientific Reports·Feng B QuanClaire Wyart
Jul 31, 2019·Nature Neuroscience·Caroline L WeeAdam D Douglass
Nov 7, 2017·Cell·Matthew Lovett-BarronKarl Deisseroth
Sep 18, 2020·Molecular and Cellular Endocrinology·Luis Fabián Canosa, Juan Ignacio Bertucci
Aug 3, 2021·Frontiers in Molecular Neuroscience·Laura Corradi, Alessandro Filosa
Oct 12, 2017·Environmental Science & Technology·William A ThompsonMathilakath M Vijayan

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Methods Mentioned

BETA
confocal microscopy

Software Mentioned

Amira
penkb
Adobe Illustrator

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