Coexpression of auxiliary Kvβ2 subunits with Kv1.1 channels is required for developmental acquisition of unique firing properties of zebrafish Mauthner cells

Journal of Neurophysiology
Takaki WatanabeYoichi Oda

Abstract

Each neuron possesses a unique firing property, which is largely attributed to heterogeneity in the composition of voltage-gated ion channel complexes. Zebrafish Mauthner (M) cells, which are bilaterally paired giant reticulospinal neurons (RSNs) in the hindbrain and induce rapid escape behavior, generate only a single spike at the onset of depolarization. This single spiking is in contrast with the repetitive firing of the M cell's morphologically homologous RSNs, MiD2cm and MiD3cm, which are also involved in escapes. However, how the unique firing property of M cells is established and the underlying molecular mechanisms remain unclear. In the present study, we first demonstrated that the single-spiking property of M cells was acquired at 4 days postfertilization (dpf), accompanied by an increase in dendrotoxin I (DTX)-sensitive low-threshold K(+) currents, prior to which the M cell repetitively fires as its homologs. Second, in situ hybridization showed that among DTX-sensitive Kv1 channel α-subunits, zKv1.1a was unexpectedly expressed even in the homologs and the bursting M cells at 2 dpf. In contrast, zKvβ2b, an auxiliary β-subunit of Kv1 channels, was expressed only in the single-spiking M cells. Third, zKv1.1a expressed ...Continue Reading

References

Feb 1, 1991·The Journal of Comparative Neurology·R K Lee, R C Eaton
May 28, 1990·Brain Research·J NissanovR DiDomenico
Feb 1, 1988·Pflügers Archiv : European journal of physiology·M Lindau, E Neher
Sep 8, 1986·The Journal of Comparative Neurology·W K MetcalfeC B Kimmel
Sep 8, 1986·The Journal of Comparative Neurology·B Mendelson
Jan 29, 1996·The Journal of Comparative Neurology·C Haddon, J Lewis
Nov 5, 1997·The Journal of Biological Chemistry·E A AcciliB A Wible
Nov 30, 1998·Science·A AmoresJ H Postlethwait
Apr 1, 1999·Annual Review of Physiology·D Oertel
Aug 11, 2000·Toxicon : Official Journal of the International Society on Toxinology·A L Harvey
Oct 4, 2000·Nature Genetics·A Nasevicius, S C Ekker
Jun 5, 2003·Journal of Neurophysiology·Jason S Rothman, Paul B Manis
Jan 1, 1963·Journal of Neurophysiology·T FURUKAWA, E J FURSHPAN
Jan 17, 2004·The European Journal of Neuroscience·Margaret Barnes-DaviesIan D Forsythe
Apr 2, 2004·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Hisako Nakayama, Yoichi Oda
Aug 27, 2004·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Iwao Fukui, Harunori Ohmori
May 5, 2006·Journal of Neurophysiology·Joshua X Gittelman, Bruce L Tempel
May 4, 2007·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Harold A Burgess, Michael Granato
Oct 11, 2007·The Journal of Comparative Neurology·Theresa M SzaboDonald S Faber
Apr 12, 2008·Development·Judith S Eisen, James C Smith
Aug 8, 2008·Journal of Neurophysiology·Ricardo H PinedaAngeles B Ribera
Oct 17, 2008·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Tsunehiko Kohashi, Yoichi Oda
Oct 17, 2008·Physiological Reviews·Helene VacherJames S Trimmer
Mar 6, 2009·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Masashi TanimotoYoichi Oda
May 29, 2009·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Chie SatouShin-ichi Higashijima
Apr 16, 2010·Physiological Reviews·Olaf Pongs, Jürgen R Schwarz
Jun 4, 2010·The Journal of Physiology·Jamie JohnstonConny Kopp-Scheinpflug
Sep 22, 2010·The Journal of Physiology·Brian K HoffpauirGeorge A Spirou
Jan 5, 2011·Proceedings of the National Academy of Sciences of the United States of America·Minoru KoyamaJoseph Fetcho
Jan 7, 2011·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·John J Perkowski, Geoffrey G Murphy
Mar 2, 2011·The Journal of Cell Biology·Hélène VacherJames S Trimmer
Apr 28, 2012·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Tsunehiko KohashiYoichi Oda
Jun 5, 2012·Biochimica Et Biophysica Acta·Alberto E PeredaJohn E Rash

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Citations

Nov 23, 2017·Proceedings of the National Academy of Sciences of the United States of America·Limor FreifeldEdward S Boyden
Sep 13, 2019·Developmental Dynamics : an Official Publication of the American Association of Anatomists·Justyna Jędrychowska, Vladimir Korzh
Jun 6, 2020·Current Biology : CB·Jessica C NelsonMichael Granato

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