Coexpression of CD5 and CD43 predicts worse prognosis in diffuse large B-cell lymphoma

Cancer Medicine
Xiao-bo MaYin-ping Wang

Abstract

Both CD5 and CD43 are expressed on the surface of B lymphocytes of definite phase and associated with the adverse outcome in diffuse large B-cell lymphoma (DLBCL). However, the relationship between CD5 and CD43 expression and the prognostic value of CD5/CD43 coexpression in DLBCL are unknown. We herein determined the correlation between CD5 and CD43 expression, as separate factors or in combination, with the clinicopathological features and survival of 200 patients with DLBCL receiving standard chemotherapy with or without rituximab. Among these DLBCL patients, CD5 expression, CD43 expression, and CD5/CD43 coexpression were detected in 18 (9%), 57 (27%), and 10 (5%) patients, respectively, and all were positively correlated with advanced age and nongerminal cell type. CD5-positive and CD43-positive DLBCL patients had poorer event-free survival (EFS, P < 0.001) and overall survival (OS, P < 0.001) than CD5-negative and CD43-negative patients, respectively. CD5/CD43 coexpression was correlated with a significantly worse prognosis than CD5 or CD43 expression alone. Univariate analysis showed that CD5 expression, CD43 expression, and CD5/CD43 coexpression were all adverse prognostic factors for DLBCL patient survival, and CD5/CD43 ...Continue Reading

References

Apr 1, 1992·Cellular Immunology·A W Butch, M H Nahm
Jul 1, 1991·Proceedings of the Society for Experimental Biology and Medicine·M T KasaianP Casali
Nov 1, 1991·Immunology Today·A B Kantor
Jan 1, 1989·Advances in Immunology·T J Kipps
Apr 20, 1989·The New England Journal of Medicine·J J YunisG Frizzera
Apr 1, 1989·Proceedings of the National Academy of Sciences of the United States of America·C S ShelleyA S Whitehead
Oct 1, 1986·Immunological Reviews·R R Hardy, K Hayakawa
Apr 3, 1987·Science·R R HardyT Kishimoto
Jan 1, 1994·Advances in Immunology·R R Hardy, K Hayakawa
Jan 17, 1995·Proceedings of the National Academy of Sciences of the United States of America·L L DragoneJ G Frelinger
Sep 30, 1993·The New England Journal of Medicine·UNKNOWN International Non-Hodgkin's Lymphoma Prognostic Factors Project
Jan 1, 1993·Annual Review of Immunology·A B Kantor, L A Herzenberg
Dec 29, 1998·Immunology Today·J R OstbergJ G Frelinger
Jun 17, 2000·Current Opinion in Immunology·K Hayakawa, R R Hardy
Jan 25, 2002·The New England Journal of Medicine·Bertrand CoiffierChristian Gisselbrecht
Jun 25, 2008·Annals of Oncology : Official Journal of the European Society for Medical Oncology·D EnnishiK Hatake
Jan 27, 2009·Annals of Oncology : Official Journal of the European Society for Medical Oncology·P WentS Dirnhofer
May 2, 2009·Clinical Lymphoma & Myeloma·Zdravko MitrovicBoris Labar
Aug 27, 2009·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·William W L ChoiWing C Chan
Jan 12, 2011·The Journal of Experimental Medicine·Daniel O GriffinThomas L Rothstein
Jan 10, 2012·Annual Review of Immunology·Claudia Mauri, Anneleen Bosma
May 23, 2013·American Journal of Hematology·Preetesh JainSusan O'Brien
Nov 22, 2013·PloS One·Nohemi Camacho-ConchaGustavo Pedraza-Alva
Dec 21, 2013·Molecular Cancer Therapeutics·Franca Maria TuccilloGiuseppe Scala
Apr 23, 2015·Immunity·Elizabeth C Rosser, Claudia Mauri
Sep 5, 2015·European Journal of Immunology·Richard R Hardy, Kyoko Hayakawa
Jan 11, 2017·Cytometry. Part B, Clinical Cytometry·Marc SorigueJavier Grau

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Citations

Jun 10, 2020·Journal of Bioenergetics and Biomembranes·Yuan LiShuaihua Wang
Jan 23, 2021·Cancers·Barbara MuzAbdel Kareem Azab
Jul 22, 2021·Leukemia & Lymphoma·Urshila Durani, Stephen M Ansell

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biopsy

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SPSS

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