Coexpression of erythopoietin and erythopoietin receptor in sporadic clear cell renal cell carcinoma

Cancer Biology & Therapy
Kan GongYanqun Na

Abstract

Clear cell renal cell carcinoma (CCRCC) is the most common renal carcinoma and it is often associated with von Hippel-Lindau disease (VHL) gene mutations. CCRCCs with VHL mutations demonstrate hypoxia-inducible factor (HIF) overexpression as well as increased expression of vascular endothelial growth factor (VEGF). Recently, the erythropoietin (Epo) has been found to be upregulated in renal and other tumors associated with VHL disease. Furthermore, Epo and Epo receptor (EpoR) coexpression has also been reported in these tumors. The results provided strong evidence that an autocrine loop is involved in tumorigenesis in VHL disease. We investigated whether Epo and EpoR coexpression also occurs in sporadic CCRCC. Fifty-four sporadic CCRCCs were analyzed. VHL gene mutations were detected in 30 out of 54 tumors. Coexpression of Epo and EpoR was detected in 50 out of 54 tumors regardless of their VHL mutation status. The results suggest that coexpression of Epo and EpoR plays an important role in tumorigenesis of sporadic CCRCC.

Citations

Jun 20, 2013·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Chen-chen FengQiang Ding
Mar 30, 1995·International Journal of Radiation Oncology, Biology, Physics·P MauchH J Deeg
Jan 12, 2013·BMC Cancer·Christudas MoraisGlenda C Gobe
Jul 21, 2007·International Journal of Cancer. Journal International Du Cancer·Michael S WiesenerKai-Uwe Eckardt
Jun 8, 2012·FEBS Letters·Hannah L Bader, Tien Hsu
Jul 30, 2016·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Tania Romina StoyanoffMaría Victoria Aguirre
Oct 20, 2018·Kidney Cancer·Daniel Beltrame FerreiraStênio de Cássio Zequi
Nov 28, 2007·Annual Review of Pathology·Tony E Walshe, Patricia A D'Amore

❮ Previous
Next ❯

Related Concepts

Related Feeds

Adenocarcinoma, Clear Cell

Clear Cell Adenocarcinoma is a tumor that arises in the female genital tract and is characterized by cells that appear clear under the microscope. Discover the latest research here.

Arterial-Venous in Development & Disease

Arterial-venous development may play a crucial role in cardiovascular diseases. Here is the latest research.