Coexpression of vasoactive intestinal polypeptide and substance P in reinnervating pulpal nerves and in trigeminal ganglion neurones after axotomy of the inferior alveolar nerve in the rat

Archives of Oral Biology
Inge FristadInger Hals Kvinnsland

Abstract

The effect of this axotomy on the expression of vasoactive intestinal polypeptide (VIP) in trigeminal ganglion neurones and nerve fibres in the first molar was examined immunohistochemically 3 weeks postsurgically in rats. A distinct upregulation of VIP-like immunoreactivity was found in 3 to 4% of the neurones (mean dia., 20.9 +/- 0.45 microns; mean cross-sectional area, 367 +/- 13.2 microns 2) in the mandibular region after axotomy. An almost complete coexpression was registered in neurones upregulated for VIP and growth-associated protein 43. Coexpression of VIP and substance P (SP) was found in a small number of the immunoreactive (IR) small-sized neurones, mainly in those in which VIP and SP were both weakly immunoreactive. In the uninjured ganglion, weakly labelled VIP-positive granules were frequently traced at high magnification in the cytoplasm of small neurones. No VIP-IR fibres were found in the control molar pulp, except for a few in the root pulp near the apex. However, 3 weeks after axotomy, a number of VIP-containing nerve fibres were found in the molar pulp and apical periodontium. Coarse VIP-IR fibres directed towards the odontoblast layer were a common finding. In some of these fibres VIP was shown to colocali...Continue Reading

References

Mar 1, 1992·Archives of Oral Biology·J LuthmanT Hökfelt
Jan 1, 1984·Annales d'endocrinologie·G Pelletier
Oct 1, 1981·Proceedings of the National Academy of Sciences of the United States of America·P J MagistrettiF E Bloom
Jan 1, 1980·Acta Odontologica Scandinavica·R UddmanF Sundler

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Citations

Nov 9, 2002·Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontics·Jin Jiang, Jianguo Gu
Mar 6, 2003·Microscopy Research and Technique·Margaret R ByersTakeyasu Maeda

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