Coffee and Caffeine Are Associated With Decreased Risk of Advanced Hepatic Fibrosis Among Patients With Hepatitis C

Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association
Natalia KhalafHashem B El-Serag

Abstract

Coffee or caffeine has been proposed to protect against hepatic fibrosis, but few data are available on their effects in patients with chronic hepatitis C virus (HCV) infection. We conducted a cross-sectional study of veterans with chronic HCV infection to evaluate the association between daily intake of caffeinated and decaffeinated coffee, tea, and soda, and level of hepatic fibrosis, based on the FibroSURE test (BioPredictive, Paris, France) (F0-F3, mild [controls] vs. F3/F4-F4, advanced). Models were adjusted for multiple potential confounders including age, alcohol abuse, and obesity. Among 910 patients with chronic HCV infection, 98% were male and 38% had advanced hepatic fibrosis. Daily intake of caffeinated coffee was higher among controls than patients with advanced fibrosis (1.37 vs. 1.05 cups/d; P = .038). In contrast, daily intake of caffeinated tea (0.61 vs. 0.56 cups/d; P = .651) or soda (1.14 vs. 0.95 cans/d; P = .106) did not differ between the groups. A higher percentage of controls (66.0%) than patients with advanced fibrosis (57.9%) consumed 100 mg or more of caffeine daily from all sources (P = .014); controls also received a larger proportion of their caffeine from coffee (50.2% vs. 43.0%; P = .035). Hepato...Continue Reading

References

May 1, 1993·European Journal of Epidemiology·E CasigliaG B Ambrosio
Jun 13, 1996·Biochimica Et Biophysica Acta·T P DevasagayamP C Kesavan
Jul 27, 2001·Journal of Clinical Epidemiology·S HonjoN Yoshizawa
Mar 19, 2002·Annals of Epidemiology·Silvano GallusCarlo La Vecchia
Jun 18, 2002·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·C CavinB Schilter
Jul 24, 2003·Annals of Epidemiology·Aage Tverdal, Svetlana Skurtveit
Aug 6, 2003·Medicine and Science in Sports and Exercise·Cora L CraigPekka Oja
Feb 17, 2005·Journal of the National Cancer Institute·Karin B MichelsEdward Giovannucci
May 14, 2005·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Christophe HézodeAriane Mallat
Jul 7, 2005·JAMA : the Journal of the American Medical Association·Rob M van Dam, Frank B Hu
May 16, 2006·Gastroenterology·Gioacchino LeandroUNKNOWN HCV Meta-Analysis (on) Individual Patients' Data Study Group
Jun 15, 2006·Archives of Internal Medicine·Arthur L KlatskyGary D Friedman
Aug 12, 2006·Journal of Hepatology·Francesco Negro
Aug 19, 2006·Hepatology Research : the Official Journal of the Japan Society of Hepatology·Satoko OhfujiYoshio Hirota
May 9, 2007·Gastroenterology·Susanna C Larsson, Alicja Wolk
Jun 21, 2007·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Francesca BraviCarlo La Vecchia
Feb 12, 2008·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Zhongsheng PengBruce N Cronstein
Jul 5, 2008·Nucleosides, Nucleotides & Nucleic Acids·Zhongsheng PengBruce N Cronstein
Aug 14, 2009·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Neal D FreedmanUNKNOWN HALT-C Trial Group
Dec 25, 2009·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Apurva A ModiJay H Hoofnagle
Aug 23, 2011·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Donna L WhiteHashem B El-Serag
Nov 9, 2011·Alimentary Pharmacology & Therapeutics·A BirerdincZ M Younossi
Aug 18, 2012·Journal of Applied Toxicology : JAT·Jonathan ArauzPablo Muriel
Mar 16, 2013·Alcohol and Alcoholism : International Journal of the Medical Council on Alcoholism·Joanna DanielssonOnni Niemelä
May 11, 2013·Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association·Francesca BraviCarlo La Vecchia
Aug 28, 2013·Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association·Fasiha KanwalHashem B El-Serag
Oct 1, 2013·Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association·Ina Marie AndersenJohannes Roksund Hov
Nov 10, 2013·Journal of Gastroenterology and Hepatology·Shaohua ChenGeoffrey C Farrell
Nov 28, 2013·The Brazilian Journal of Infectious Diseases : an Official Publication of the Brazilian Society of Infectious Diseases·Silmara Rodrigues MachadoLuciana de Carvalho
Jan 21, 2014·Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association·Craig LammertKonstantinos N Lazaridis
Apr 29, 2014·Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association·Radhika Kumari, W Ray Kim

❮ Previous
Next ❯

Citations

May 20, 2016·Journal of Clinical and Experimental Hepatology·Manav Wadhawan, Anil C Anand
Jun 29, 2016·Clinics and Research in Hepatology and Gastroenterology·Veeravich JaruvongvanichSikarin Upala
Jan 19, 2018·Nutrients·Nicola VeroneseUNKNOWN MICOL Group
Jan 20, 2018·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Jasmohan S BajajPatrick M Gillevet
May 16, 2015·F1000Research·Jordan J FeldJonathan A Dranoff
Feb 15, 2018·Virology Journal·Ana Carolina Gomes JardimMark Harris
Jul 5, 2019·Cell Adhesion & Migration·Angkhana NilnumkhumVisith Thongboonkerd
Sep 28, 2016·European Journal of Gastroenterology & Hepatology·Karn WijarnpreechaPatompong Ungprasert
Jun 10, 2017·World Journal of Hepatology·Ryan D HeathVeysel Tahan
Jan 21, 2016·Clinical Liver Disease·Vignan Manne, Sammy Saab
Feb 23, 2019·Scientific Reports·Ana ArpónJ Alfredo Martínez
Dec 22, 2017·The Journal of Nutritional Biochemistry·Minkyung BaeJi-Young Lee

❮ Previous
Next ❯

Related Concepts

Related Feeds

Antivirals

Antivirals are medications that are used specifically for treating viral infections. Discover the latest research on antivirals here.

Antivirals (ASM)

Antivirals are medications that are used specifically for treating viral infections. Discover the latest research on antivirals here.

Related Papers

American Journal of Epidemiology
H D SessoC H Hennekens
Hepatology : Official Journal of the American Association for the Study of Liver Diseases
Apurva A ModiJay H Hoofnagle
© 2021 Meta ULC. All rights reserved