Coffee consumption and the risk of rheumatoid arthritis and systemic lupus erythematosus: a Mendelian randomization study

Clinical Rheumatology
Sang-Cheol Bae, Young Ho Lee

Abstract

We aimed to analyze the causal association between coffee consumption and the risk of rheumatoid arthritis (RA) and systemic lupus erythematosus (SLE). We performed a two-sample Mendelian randomization (MR) analysis using the inverse-variance weighted (IVW), MR-Egger regression, and weighted median methods. We used publicly available summary statistics datasets of coffee consumption genome-wide association studies (GWASs) as an exposure variable and RA and SLE GWASs as outcomes. Four single-nucleotide polymorphisms (SNPs) from GWASs of coffee consumption were selected as instrumental variables (IVs) to improve inference: NCARD (rs16868941), POR (rs17685), CYP1A1 (rs2470893), and LAMB4 (rs382140). The IVW method showed a causal association between coffee consumption and RA (beta = 0.770, SE = 0.279, p = 0.006). MR-Egger regression revealed that directional pleiotropy was unlikely to be biasing the result (intercept = - 0.145, p = 0.451). While the MR-Egger analysis showed no causal association between coffee consumption and RA (beta = 2.744, SE = 1.712, p = 0.355), the weighted median approach demonstrated a causal association between coffee consumption and RA (beta = 0.751, SE = 0.348, p = 0.031). However, the associations base...Continue Reading

References

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Sep 4, 2012·Clinical Rheumatology·Gwan Gyu SongYoung Ho Lee
Jul 19, 2013·American Journal of Epidemiology·Brandon L Pierce, Stephen Burgess
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Oct 8, 2014·Molecular Psychiatry·UNKNOWN Coffee and Caffeine Genetics ConsortiumDaniel I Chasman
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Mar 25, 2017·International Journal of Epidemiology·Fernando Pires HartwigGeorge Davey Smith
May 10, 2017·Autoimmunity Reviews·Kassem SharifYehuda Shoenfeld

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