Coffee consumption in aged mice increases energy production and decreases hepatic mTOR levels

Nutrition
Keita TakahashiAkihito Ishigami

Abstract

Coffee, one of the world's most consumed beverages, has many benefits. Some studies have reported the effects of coffee on aging. The aim of this study was to investigate the locomotor activity, energy metabolism, and lipid metabolism of aged (20-mo-old) mice given coffee. Aged C57 BL/6 NCr mice were divided into three groups: controls that were not given coffee (n = 9), a group that received 0.1% caffeinated coffee (n = 9), and a group that received 0.1% decaffeinated coffee (n = 9). This regimen continued for 17 wk until mice reached the age of 24 mo. Regular and decaffeinated coffee consumption decreased plasma-free fatty acid levels, increased hepatic adenosine triphosphate content, and decreased total mammalian target of rapamycin (mTOR) and phosphorylated mTOR (p-mTOR) protein content in the liver. However, no differences were found in the protein or activity levels of Akt, adenosine monophosphate-activated protein kinase (AMPK), p70 S6 kinase, or sterol regulatory element-binding protein 1, proteins that are upstream or downstream of the mTOR complex 1 (mTORC1)-related pathways. Regular coffee consumption increased food and water intake, locomotor activity, the volume of carbon dioxide production, and the respiration exc...Continue Reading

Citations

Aug 31, 2017·Aging·Keita Takahashi, Akihito Ishigami
Nov 7, 2019·Food Science and Biotechnology·Renalison Farias-PereiraYeonhwa Park
Jun 20, 2020·Critical Reviews in Food Science and Nutrition·Raffaella Colombo, Adele Papetti
Oct 7, 2018·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Naiara StefanelloMaria Rosa Chitolina Schetinger

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