Coffee extracts suppress tryptophan breakdown in mitogen-stimulated peripheral blood mononuclear cells

Journal of the American College of Nutrition
Johanna M GostnerDietmar Fuchs

Abstract

Coffee consumption is considered to exert an influence on mood, the immune system, cardiovascular disease, and cancer development, but the mechanisms of action of coffee and its compounds are only partly known and understood. Immunomodulatory effects of filtered extracts of coffee and decaffeinated coffee as well as coffee compounds were investigated in human peripheral blood mononuclear cells (PBMCs) stimulated with mitogen phytohemagglutinin (PHA). The activation of PBMCs was monitored by the breakdown of tryptophan to kynurenine via enzyme indoleamine 2,3-dioxygenase (IDO) and the production of the immune activation marker neopterin by GTP-cyclohydrolase I (GCH1). Both of these biochemical pathways are induced during cellular immune activation in response to the Th1-type cytokine interferon-γ (IFN-γ). Filtered extracts of coffee and decaffeinated coffee both suppressed tryptophan breakdown and neopterin formation in mitogen-stimulated PBMCs efficiently and in a dose-dependent manner. Of 4 coffee compounds tested individually, only gallic acid and less strong also caffeic acid had a consistent suppressive influence but also affected cell viability, whereas pure caffeine and chlorogenic acid exerted no relevant effect in the P...Continue Reading

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Citations

Oct 10, 2015·Allergy·Betul BuyuktiryakiCansin Sackesen
Feb 24, 2015·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Johanna M GostnerDietmar Fuchs
Mar 13, 2018·Natural Product Research·Hasan KırmızıbekmezErdem Yeşilada
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Aug 27, 2015·International Journal of Tryptophan Research : IJTR·Vikram Mehraj, Jean-Pierre Routy
Aug 31, 2017·Critical Reviews in Food Science and Nutrition·Büşra Başar Gökcen, Nevin Şanlier
Jun 7, 2019·Journal of the National Cancer Institute·Erikka LoftfieldNeal D Freedman
Oct 12, 2018·Pharmacological Reports : PR·Monika TurskaWaldemar Turski
Nov 13, 2015·Current Opinion in Clinical Nutrition and Metabolic Care·Barbara StrasserDietmar Fuchs

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Methods Mentioned

BETA
enzyme-linked immunosorbent assays
FCS

Software Mentioned

SPSS
CalcuSyn
ProStar

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