Coffee intake during pregnancy and childhood acute leukemia - A cohort study

Cancer Epidemiology
Carina Nkoyo MadsenBodil H Bech

Abstract

To estimate a possible association between coffee intake during pregnancy and risk of childhood acute leukemia by using a cohort design. We included data from two birth cohorts; the Danish National Birth Cohort and the Aarhus Birth Cohort. Recruitment of 141,216 eligible pregnancies occurred from 1 August 1989 to 31 December 2012. Information on maternal prenatal coffee intake and covariates was collected in early second trimester of pregnancy. Information on childhood AL diagnosed in offspring was obtained from the Danish National Patient Register. We used competing risk time-to-event regression analysis, using the pseudo-observation method to estimate risk ratio (RR) with no coffee intake during pregnancy considered the reference group. In total 96 children were diagnosed with AL, hereof 73 with acute lymphoblastic leukemia (ALL). Coffee intake of 0.5-3 cups/day during pregnancy was not associated with a higher risk of childhood AL; aRR = 0.89, 95 % confidence interval (CI): 0.48, 1.65, however, an intake of >3 cups/day resulted in aRR = 1.37, 95 % CI: 0.56, 3.32. Only including ALL as outcome we found similar results; aRR = 0.80, 95 % CI: 0.37-1.74 and aRR = 1.46 95 % CI: 0.52-4.09, respectively. We found no significant asso...Continue Reading

References

Jan 1, 1997·British Journal of Cancer·E PetridouF Tzortzatou
Jan 5, 2002·Scandinavian Journal of Public Health·J OlsenC Søndergaard
Feb 1, 1962·Biochemical Pharmacology·A GOLDSTEIN, R WARREN
Aug 2, 2005·Bioelectromagnetics·Tracy Lightfoot
Nov 15, 2005·European Journal of Cancer Prevention : the Official Journal of the European Cancer Prevention Organisation (ECP)·Jacqueline ClavelMarie-Anne Loriot
Nov 18, 2005·Cancer Detection and Prevention·Florence MenegauxJacqueline Clavel
Jun 7, 2006·Epidemiology·Ellen Aagaard NohrJorn Olsen
Jun 15, 2007·Paediatric and Perinatal Epidemiology·Florence MenegauxJacqueline Clavel
Mar 30, 2010·European Journal of Epidemiology·Tine Neermann JacobsenMorten Frydenberg
Feb 14, 2012·Chemico-biological Interactions·Joseph Wiemels
Feb 14, 2013·Cancer Causes & Control : CCC·Audrey BonaventureJacqueline Clavel
Sep 26, 2013·American Journal of Obstetrics and Gynecology·Jian ChengDongdong Fan
Jan 15, 2014·Lifetime Data Analysis·Stefan Nygaard HansenErik Thorlund Parner

❮ Previous
Next ❯

Related Concepts

Related Feeds

AML: Role of LSD1 by CRISPR (Keystone)

Find the latest rersearrch on the ability of CRISPR-Cas9 mutagenesis to profile the interactions between lysine-specific histone demethylase 1 (LSD1) and chemical inhibitors in the context of acute myeloid leukemia (AML) here.

Acute Myeloid Leukaemia & RNA

Acute myeloid leukaemia (AML) is a common hematological type of cancer. As the population ages, there has been a rise in the frequency of AML. RNA expression has been used to see if there are different genetic profiles that exist within AML and whether these may underpin the variations in survival rates. Here is the latest research on AML and RNA.

Acute Myeloid Leukemia

Acute myeloid leukemia (AML) is a clinically and genetically heterogeneous disease with approximately 20,000 cases per year in the United States. AML also accounts for 15-20% of all childhood acute leukemias, while it is responsible for more than half of the leukemic deaths in these patients. Here is the latest research on this disease.