Cofilin and profilin: partners in cancer aggressiveness

Biophysics Reviews
Joelle V F CoumansPierre D J Moens

Abstract

This review covers aspects of cofilin and profilin regulations and their influence on actin polymerisation responsible for cell motility and metastasis. The regulation of their activity by phosphorylation and nitration, miRs, PI(4,5)P2 binding, pH, oxidative stress and post-translational modification is described. In this review, we have highlighted selected similarities, complementarities and differences between the two proteins and how their interplay affects actin filament dynamics.

References

Mar 8, 1991·Science·P J Goldschmidt-ClermontT D Pollard
Jan 29, 1988·Biochemical and Biophysical Research Communications·A HanssonM Ingelman-Sundberg
Nov 10, 1995·The Journal of Biological Chemistry·D B OstranderG M Carman
Jan 5, 1996·Biochemical and Biophysical Research Communications·M BabichC R Clark
May 17, 2000·The Journal of Experimental Medicine·J JankeS Scherneck
Jun 1, 2001·Cellular Signalling·B Vemuri, S S Singh
Jan 29, 2002·Journal of Molecular Biology·Sharon YeohAlan Weeds
Dec 24, 2002·Trends in Cell Biology·James R Bamburg, O'Neil P Wiggan
Feb 26, 2003·Cell·Thomas D Pollard, Gary G Borisy
May 6, 2003·Experimental Cell Research·Petra SkareRoger Karlsson
Dec 24, 2003·Cell Motility and the Cytoskeleton·Partha Roy, Ken Jacobson
Jan 31, 2004·Cellular Signalling·K SathishSurya S Singh
Jun 11, 2004·Genes to Cells : Devoted to Molecular & Cellular Mechanisms·Go TomiyoshiKensaku Mizuno
Jun 29, 2004·Nature Cell Biology·Xiaolong YangTian Xu
Jul 13, 2004·Trends in Cell Biology·Ville O PaavilainenPekka Lappalainen
Sep 16, 2004·Nature Reviews. Molecular Cell Biology·Paul A Janmey, Uno Lindberg
Nov 13, 2004·The EMBO Journal·Si Tuen Lee-HoeflichLiliana Attisano
Dec 14, 2004·Molecular Human Reproduction·Heike ObermannChristiane Kirchhoff
Dec 24, 2004·Journal of Cell Science·Marcell LedererMartin Rothkegel
Jan 27, 2005·The Journal of Biological Chemistry·Yan WangKensaku Mizuno
Jul 12, 2005·Annual Review of Biomedical Engineering·Song LiShu Chien
Nov 18, 2005·Nitric Oxide : Biology and Chemistry·S KasinaSurya S Singh
Dec 13, 2005·Current Opinion in Cell Biology·Timothy Y HuangGary M Bokoch
Jan 24, 2006·Journal of Biochemistry·S KasinaSurya S Singh
May 16, 2006·Apoptosis : an International Journal on Programmed Cell Death·Cathrine NilssonKarin Ollinger

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Citations

Jul 15, 2020·Biophysics Reviews·Rhonda J Davey, Pierre Dj Moens
Nov 12, 2020·Biology·Jaya Aseervatham
Jul 31, 2020·Current Opinion in Physiology·Susana Lechuga, Andrei I Ivanov
Jun 27, 2021·International Journal of Biological Macromolecules·Jia Jin Hiu, Michelle Khai Khun Yap
Jul 16, 2021·Chemico-biological Interactions·David Hernandez-Toledano, Libia Vega
Sep 25, 2020·Experimental and Molecular Pathology·Yoshifumi S HirokawaMasatoshi Watanabe

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Methods Mentioned

BETA
nucleotide exchange
ubiquitination

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