PMID: 20099233Jan 26, 2010Paper

Cogan syndrome: confocal microscopy assessment of corneal damage

European Journal of Ophthalmology
Isabella PellistriJelka G Orsoni

Abstract

To perform in vivo assessment of corneal alterations in patients with Cogan syndrome (CS) and to correlate these findings with prior histopathologic descriptions. Four consecutive patients (8 eyes) presenting with typical CS underwent confocal microscopy examination. At the moment of evaluation, ocular inflammation was quiescent in all the patients. The images were studied singularly, and then compared to those obtained from 5 healthy controls. Statistical analysis was performed with Student t test. All the cases showed multiple brightly reflective deposits in the stroma with moderate reflectivity of the surrounding stromal tissue. The outer corneal layers and the endothelium were spared. In 3/4 of the patients, the nerve fibers of the subepithelial plexus were thin and poorly reflective, with interruptions and lack of the typical branching pattern. No cells different from keratocytes could be detected in either case or control eyes. Corneal vascularization was present in one case. In CS-affected eyes, corneal thickness was 552+/-62 microm on average, and endothelial cell count was 2466+/-288 cells/mm(2). Statistical significance was not reached compared to the control group. Confocal microscopy was able to provide detailed ima...Continue Reading

References

Jan 1, 1989·Acta Ophthalmologica. Supplement·D G Cogan, T Kuwabara
Mar 1, 1986·The Annals of Otology, Rhinology, and Laryngology·G J PeetersW H Hoefnagels
Aug 1, 1984·Ophthalmology·L M Cobo, B F Haynes
May 27, 2003·Investigative Ophthalmology & Visual Science·Ilpo S J TuominenTimo M T Tervo
Aug 11, 2004·Archives of Ophthalmology·Ehud ZamirAbraham Solomon
Nov 24, 2005·Investigative Ophthalmology & Visual Science·Dipika V Patel, Charles N J McGhee
Sep 16, 2006·Rheumatology·H Martínez-OsorioM Calonge
Nov 27, 2007·Rheumatic Diseases Clinics of North America·Mehrdad Mazlumzadeh, Eric L Matteson
Feb 1, 2008·Investigative Ophthalmology & Visual Science·Edoardo VillaniRoberto Ratiglia
Aug 14, 2009·American Journal of Ophthalmology·Jay C ErieSanjay V Patel

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Citations

Aug 30, 2011·Optometry and Vision Science : Official Publication of the American Academy of Optometry·Francesco SemeraroCiro Costagliola
Apr 28, 2021·Journal français d'ophtalmologie·T AndresD Touboul

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