Cognate CD4+ T-cell-dendritic cell interactions induce migration of immature dendritic cells through dissolution of their podosomes

Blood
Cinzia NobileClaire Hivroz

Abstract

Dendritic cells (DCs) control T cell-based immunity. To do so they need to mature and migrate to sites of T-cell priming. We have previously shown that cognate interactions of human CD4+ T cells with DCs induce DC maturation. We show here that CC chemokines produced during antigen-specific T-DC interactions also induce strong morphologic modifications and migration of immature DCs. These modifications are required for efficient T-cell activation. Moreover, we show that CC chemokines produced during antigen-specific DC-T-cell interactions induce the dissolution of structures involved in cell motility and present on immature DCs (ie, podosomes). We thus propose a model in which chemokines secreted during Ag-specific contact between T cells and DCs induce disassembly of interacting and neighboring immature DC podosomes, leading to recruitment of more immature DCs toward sites of antigenic stimulation and to amplification of T-cell responses.

References

Nov 1, 1984·The Journal of Cell Biology·P C MarchisioA Zambonin-Zallone
Oct 1, 1994·The Journal of Experimental Medicine·C CauxJ Banchereau
Oct 1, 1996·The Journal of Experimental Medicine·T De SmedtM Moser
Mar 21, 1998·The Journal of Experimental Medicine·S SozzaniA Mantovani
Apr 1, 1998·Nature·J Banchereau, R M Steinman
Oct 1, 1998·European Journal of Immunology·F SallustoA Lanzavecchia
Dec 10, 1998·International Immunology·A SnijdersM L Kapsenberg
Feb 2, 1999·The Journal of Experimental Medicine·J G Cyster
Feb 17, 1999·The Journal of Experimental Medicine·F Sallusto, A Lanzavecchia
Feb 17, 1999·The Journal of Experimental Medicine·C RobertT S Kupper
Oct 27, 1999·Proceedings of the National Academy of Sciences of the United States of America·A CarfíD C Wiley
Jun 3, 2000·Annual Review of Immunology·J BanchereauK Palucka
Jul 3, 2003·Trends in Cell Biology·Stefan Linder, Martin Aepfelbacher
Dec 10, 2003·The Journal of Immunology : Official Journal of the American Association of Immunologists·Roman Spörri, Caetano Reis e Sousa
Dec 23, 2003·The Journal of Immunology : Official Journal of the American Association of Immunologists·Federica BenvenutiSebastian Amigorena
Dec 24, 2003·Cell Motility and the Cytoskeleton·Siobhan BurnsAdrian J Thrasher
Feb 27, 2004·Immunology and Cell Biology·Georg BehrensWilliam R Heath
Apr 7, 2004·Trends in Cell Biology·Marianne BoesHidde Ploegh
May 25, 2004·Nature Immunology·Oral AlpanPolly Matzinger
Oct 12, 2004·Nature Immunology·Christopher M SmithGabrielle T Belz
Dec 21, 2004·Springer Seminars in Immunopathology·Esther C de JongMartien L Kapsenberg
Aug 2, 2005·Nature Reviews. Immunology·Gwendalyn J RandolphMelody A Swartz
Mar 21, 2006·European Journal of Cell Biology·Yolanda CalleGareth E Jones
Jul 20, 2006·The Journal of Immunology : Official Journal of the American Association of Immunologists·Suzanne F G van HeldenFrank N van Leeuwen
Jul 25, 2006·Trends in Immunology·Antonella ViolaBarbara Molon
Sep 5, 2006·The Journal of Immunology : Official Journal of the American Association of Immunologists·Francesc MiroClaire Hivroz
Sep 12, 2006·Nature Immunology·Rachel S FriedmanMatthew F Krummel
Oct 24, 2006·The Journal of Immunology : Official Journal of the American Association of Immunologists·Paola CappelloMirella Giovarelli
Jun 16, 2007·Immunity·Christopher V CarmanTimothy A Springer

❮ Previous
Next ❯

Citations

Aug 20, 2008·Nature Immunology·Peter Friedl, Bettina Weigelin
Feb 26, 2009·Médecine sciences : M/S·Elisabeth Génot
Jun 27, 2013·PloS One·María B GanemEmilio L Malchiodi
Feb 24, 2011·Cellular Signalling·Athanassios Dovas, Dianne Cox
Jul 8, 2010·European Journal of Cell Biology·Frédéric SaltelElisabeth Génot
May 17, 2011·PloS One·Julien HussonNelly Henry
Apr 25, 2007·Immunology Letters·Julie GertnerJean-Jacques Fournié
May 17, 2011·The Journal of Immunology : Official Journal of the American Association of Immunologists·Sara MorlacchiAdelaida Sarukhan
Feb 6, 2020·Frontiers in Immunology·Sofia Noli TruantMarisa M Fernández
Oct 29, 2010·The Journal of Immunology : Official Journal of the American Association of Immunologists·Marie TourretClaire Hivroz
Oct 5, 2010·The Journal of Immunology : Official Journal of the American Association of Immunologists·Alessandra AldinucciClara Ballerini
Apr 27, 2018·Science Translational Medicine·Michela FrascoliTippi C MacKenzie

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.