PMID: 2123347Nov 1, 1990Paper

Cognate peptides induce self-destruction of CD8+ cytolytic T lymphocytes

Proceedings of the National Academy of Sciences of the United States of America
P R Walden, Herman N Eisen

Abstract

Cytotoxic T lymphocytes (CTLs) have been shown to be relatively resistant to cytolytic attack by other CTLs. We show here, however, that cloned CTLs, in the absence of other cells, are destroyed by exposure to their cognate peptides (defined as those that in association with major histocompatibility complex proteins are recognized by the antigen-specific receptor of the T cell). Destruction is proportional to peptide concentration and can be prevented by a second peptide that competes with the cognate peptide for presentation by the class I major histocompatibility complex proteins of the CTLs. The speed and extent of peptide-induced changes in the appearance of CTLs suggest that the destruction may be due primarily to self-recognition and self-destruction of individual CTLs (suicide) rather than to the destruction of some CTLs by others of the same clone in the same culture (fratricide). This effect may also take place in vivo because the appropriately timed injection of a cognate peptide into ovalbumin-immunized mice appeared to deplete their spleens of primed anti-ovalbumin CTLs. The results point to a possible physiologic mechanism for postthymic elimination of cytolytic T cells that recognize their own peptides in associat...Continue Reading

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Citations

Oct 30, 1999·European Journal of Immunology·D KägiT W Mak
Nov 1, 1991·Immunology Letters·L Fesus
Oct 1, 1992·Immunology Today·G Kroemer, C Martínez
Jun 1, 1991·Current Opinion in Immunology·G Berke
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Nov 22, 1994·Proceedings of the National Academy of Sciences of the United States of America·Y SykulevH N Eisen
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Apr 3, 2001·International Immunology·J T OpfermanP G Ashton-Rickardt

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