Abstract
Benign epilepsy with centrotemporal spikes (BECTS), the most common focal childhood epilepsy, is associated with subtle abnormalities in cognition and possible developmental alterations in brain structure when compared to healthy participants, as indicated by previous cross-sectional studies. To examine the natural history of BECTS, we investigated cognition, cortical thickness, and subcortical volumes in children with new/recent onset BECTS and healthy controls (HC). Participants were 8-15 years of age, including 24 children with new-onset BECTS and 41 age- and gender-matched HC. At baseline and 2 years later, all participants completed a cognitive assessment, and a subset (13 BECTS, 24 HC) underwent T1 volumetric magnetic resonance imaging (MRI) scans focusing on cortical thickness and subcortical volumes. Baseline cognitive abnormalities associated with BECTS (object naming, verbal learning, arithmetic computation, and psychomotor speed/dexterity) persisted over 2 years, with the rate of cognitive development paralleling that of HC. Baseline neuroimaging revealed thinner cortex in BECTS compared to controls in frontal, temporal, and occipital regions. Longitudinally, HC showed widespread cortical thinning in both hemispheres...Continue Reading
References
Feb 1, 1977·Journal of Consulting and Clinical Psychology·D T Stuss, R L Trites
Apr 1, 1991·Epilepsy Research·G A BakerD W Chadwick
Sep 14, 2000·Proceedings of the National Academy of Sciences of the United States of America·B Fischl, A M Dale
Apr 11, 2001·IEEE Transactions on Medical Imaging·B FischlA M Dale
Dec 5, 2003·Cerebral Cortex·Bruce FischlAnders M Dale
Jun 29, 2004·NeuroImage·F SégonneB Fischl
Jan 18, 2005·Epilepsy & Behavior : E&B·A PapavasiliouE Paraskevoulakos
Feb 22, 2005·Brain and Language·Cécile MonjauzeAbdelhamid Khomsi
Dec 24, 2005·Cerebral Cortex·Ronald B Postuma, Alain Dagher
Mar 31, 2006·Nature·P ShawJ Giedd
Aug 25, 2006·Brain : a Journal of Neurology·Bruce HermannMichael Seidenberg
Apr 16, 2008·Epilepsia·Peregrine Murphy KavrosDeb K Pal
Jul 29, 2008·Journal of Child Neurology·Uri Kramer
Nov 3, 2009·Epilepsy & Behavior : E&B·Julia Danielsson, Franz Petermann
Mar 8, 2011·NeuroImage·Martin Reuter, Bruce Fischl
Mar 8, 2011·Journal of the Neurological Sciences·G M OvervlietJ Hendriksen
Mar 1, 2012·Epilepsia·Jack J LinBruce P Hermann
Jun 12, 2012·Epilepsy & Behavior : E&B·Marina L NeriMarilisa M Guerreiro
Oct 2, 2012·Lancet·Jack J LinBruce P Hermann
Dec 12, 2012·The Journal of Pediatrics·Daren C JacksonBruce P Hermann
Jan 10, 2013·Epilepsia·Alexandre N DattaIris-Katharina Penner
Feb 5, 2013·Epilepsy Research·Heath R PardoeGraeme D Jackson
Feb 21, 2013·European Journal of Paediatric Neurology : EJPN : Official Journal of the European Paediatric Neurology Society·Geke M OvervlietAlbert P Aldenkamp
Nov 2, 2013·NeuroImage. Clinical·Geke M OvervlietWalter H Backes
Dec 18, 2013·European Journal of Neurology : the Official Journal of the European Federation of Neurological Societies·S E KimH W Lee
Mar 4, 2014·Epilepsy & Behavior : E&B·Nadine OserIris-Katharina Penner
Mar 22, 2014·Developmental Medicine and Child Neurology·Paul J RathouzBruce P Hermann
Jun 15, 2014·NeuroImage·Michael A SkeideAngela D Friederici
Jul 13, 2014·Brain and Language·Anna OhElizabeth W Pang
Aug 5, 2014·Annals of Neurology·Jack J LinBruce P Hermann
Sep 2, 2014·Neuron·Sara M Szczepanski, Robert T Knight
Apr 22, 2015·Seizure : the Journal of the British Epilepsy Association·Eun-Hee KimTae-Sung Ko
Citations
Mar 18, 2016·Child's Nervous System : ChNS : Official Journal of the International Society for Pediatric Neurosurgery·Chunrong LiuJiwen Wang
Jul 8, 2016·Annals of Clinical and Translational Neurology·Naim PanjwaniLisa J Strug
Jun 29, 2016·Epilepsia·Jennifer VannestTracy A Glauser
Aug 6, 2016·Epilepsy & Behavior : E&B·Vera DinkelackerSophie Dupont
Feb 1, 2017·Current Opinion in Neurology·Kees P J Braun
Apr 10, 2017·Brain and Language·M VerlyI Zink
Jun 18, 2017·Epilepsy Research·Weifang CaoDezhong Yao
Jul 11, 2018·Acta Neurologica Scandinavica·Hisako FujiwaraJennifer Vannest
Aug 28, 2018·Epilepsia·Manal SalmiPierre Szepetowski
Sep 17, 2018·Neurologia i neurochirurgia polska·P DryżałowskiJ Strzelecka
May 23, 2020·Minerva pediatrica·Laura SiriAmnon Cohen
Aug 13, 2017·Epilepsia·Steven WickensWendyl D'Souza
Feb 23, 2018·Frontiers in Neurology·Lin JiangTianyou Luo
Oct 4, 2018·Epilepsia·Camille Garcia-RamosBruce P Hermann
Jan 11, 2020·Frontiers in Neurology·Anna Elisabetta VaudanoStefano Meletti
Dec 6, 2017·Human Brain Mapping·Rong LiHuafu Chen
Jul 28, 2019·Epilepsia·Camille Garcia-RamosBruce P Hermann
Feb 28, 2017·Frontiers in Neuroscience·Emilie Bourel-PonchelFabrice Wallois
Jan 5, 2019·BMC Neurology·Ye-Hwa JunJung-Min Kim
Sep 27, 2019·Frontiers in Neurology·Emilie Bourel-PonchelFabrice Wallois
Apr 27, 2021·Frontiers in Neurology·Yiran DuanYuping Wang
Sep 15, 2020·NeuroImage. Clinical·Carolina CiumasPhilippe Ryvlin
Apr 20, 2021·Epilepsy Research·Yin XuZhiqiang Zhang
May 22, 2021·European Radiology·Qirui ZhangZhiqiang Zhang
May 26, 2021·Epilepsia Open·Stuart D W SmithDeb K Pal
Jun 1, 2021·Epilepsy & Behavior : E&B·Yasemin ÖzgenBülent Kara
Feb 27, 2020·Current Medical Imaging·Alireza NezamiNegin Koochak Shoshtari
Jul 4, 2021·Neurologic Clinics·Akshat Katyayan, Gloria Diaz-Medina
May 18, 2021·Epilepsy Currents·Barbara C JobstWilliam Davis Gaillard
Aug 25, 2021·Epilepsy & Behavior : E&B·Martina Paola ZanaboniValentina De Giorgis
Mar 30, 2020·Epilepsy & Behavior : E&B·Wen HeQianqian Wu
May 30, 2021·European Radiology·Yuting LiMei Tian