Cognition and neuropsychiatry in behavioral variant frontotemporal dementia by disease stage

Neurology
Kamalini G RanasingheBruce L Miller

Abstract

To characterize the cognitive and neuropsychiatric symptoms of patients with behavioral variant frontotemporal dementia (bvFTD) over the natural course of the disease. We examined the initial and subsequent neuropsychological test performance and neuropsychiatric symptoms in a large cohort of patients with bvFTD (n = 204) across progressive stages of disease as measured by the Clinical Dementia Rating (CDR). We also compared cognitive and neuropsychiatric impairments of patients with bvFTD to those of an age-matched cohort with Alzheimer disease (AD) dementia (n = 674). At the earliest stage (CDR = 0.5), patients with bvFTD had profound neuropsychiatric disturbances, insensitivity to errors, slower response times, and poor naming, with intact attention span, memory, and facial affect naming. Tests continuing to show progressive, statistically significant stepwise declines after the CDR = 1 stage included free recall, visuoconstruction, set-shifting, error insensitivity, semantic fluency, design fluency, emotion naming, calculations, confrontation naming, syntax comprehension, and verbal agility. At CDR = 0.5, patients with bvFTD significantly outperformed patients with AD in episodic memory and were faster in set-shifting, whil...Continue Reading

References

Jan 1, 1995·Journal of Neurology, Neurosurgery, and Psychiatry·F PasquierH Petit
Nov 1, 1993·Neurology·R D Penn, E A Mangieri
Nov 1, 1996·Journal of the International Neuropsychological Society : JINS·N A PachanaN Berman
Sep 26, 2001·Brain : a Journal of Neurology·S A BungeJ D Gabrieli
Dec 11, 2003·Cognitive and Behavioral Neurology : Official Journal of the Society for Behavioral and Cognitive Neurology·Joel H KramerBruce L Miller
Jun 5, 2004·Dementia and Geriatric Cognitive Disorders·Jennifer L WhitwellNick C Fox
Apr 23, 2005·Human Brain Mapping·Bradley R BuchsbaumKaren Faith Berman
Jun 21, 2005·Journal of Neurology, Neurosurgery, and Psychiatry·J C ThompsonD Neary
Jan 12, 2007·Journal of Cognitive Neuroscience·Junichi ChikazoeYasushi Miyashita
Jun 20, 2007·Proceedings of the National Academy of Sciences of the United States of America·Nico U F DosenbachSteven E Petersen
Jan 22, 2008·Dementia and Geriatric Cognitive Disorders·Mario F MendezRonald E Saul
Mar 4, 2008·Neuropsychology Review·Dana WittenbergJoel H Kramer
Apr 19, 2008·Neurology·M GrossmanJ Q Trojanowski
Oct 3, 2008·Brain : a Journal of Neurology·David S KnopmanNathaniel Mercaldo
Apr 21, 2009·Neuron·William W SeeleyMichael D Greicius
May 1, 2009·Journal of the International Neuropsychological Society : JINS·Katherine L PossinJoel H Kramer
Nov 11, 2009·Neuropsychology·Erin K JohnsHoward Chertkow
Dec 17, 2009·Journal of the International Neuropsychological Society : JINS·Sharon X XieMurray Grossman
Jun 8, 2010·Neurocase·Katherine L Possin
Sep 15, 2010·International Psychogeriatrics·Janine Diehl-SchmidThomas Jahn
Jun 10, 2011·Journal of Neurophysiology·B T Thomas YeoRandy L Buckner
Aug 4, 2011·Brain : a Journal of Neurology·Katya RascovskyBruce L Miller
Oct 1, 2011·Consciousness and Cognition·Mario F Mendez, Jill S Shapira
Jan 21, 2014·Trends in Cognitive Sciences·Adam R AronRussell A Poldrack
May 28, 2014·The European Journal of Neuroscience·Ryan K Jessup, John P O'Doherty

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Citations

Aug 27, 2019·European Journal of Neurology : the Official Journal of the European Federation of Neurological Societies·M CossedduA Padovani
Jun 16, 2017·Neurology·Mary K FloeterTianxia Wu
May 8, 2018·Alzheimer Disease and Associated Disorders·Valéria S BahiaMônica S Yassuda
Apr 30, 2017·Journal of Alzheimer's Disease : JAD·Noora-Maria SuhonenAnne M Remes
Jul 12, 2019·Frontiers in Neuroscience·Kasper KatiskoEino Solje
Aug 10, 2019·Frontiers in Aging Neuroscience·José Manuel Santacruz EscuderoHernando Santamaría-García
May 22, 2020·Brain : a Journal of Neurology·Alexander G MurleyJames B Rowe
Jun 18, 2020·Frontiers in Neurology·Suzanne M ShdoKatherine P Rankin
Mar 18, 2017·Journal of Alzheimer's Disease : JAD·Marta Fernández-MatarrubiaJorge Matías-Guiu
Aug 29, 2016·Journal of Alzheimer's Disease : JAD·Maxime BertouxBruno Dubois
Mar 16, 2018·Brain Imaging and Behavior·Lauren MassimoCorey T McMillan
Aug 20, 2019·Applied Neuropsychology. Adult·Andrew M Kiselica, Jared F Benge
Aug 21, 2020·Seminars in Neurology·Orit H Lesman-SegevGil D Rabinovici
Oct 20, 2020·Neurological Sciences : Official Journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology·Petronilla BattistaGiancarlo Logroscino
Sep 14, 2020·Cortex; a Journal Devoted to the Study of the Nervous System and Behavior·Raffaella MigliaccioRichard Levy
Feb 9, 2021·Journal of Alzheimer's Disease : JAD·Enrico PeiraFlavio Nobili
Feb 17, 2021·Alzheimer's & Dementia : the Journal of the Alzheimer's Association·Ignacio Illán-GalaHoward J Rosen
May 6, 2021·Human Brain Mapping·Lauren E SalminenPaul M Thompson
Jun 3, 2020·Dementia and Geriatric Cognitive Disorders·Titta KorhonenEino Solje

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