Cognition, brain atrophy, and cerebrospinal fluid biomarkers changes from preclinical to dementia stage of Alzheimer's disease and the influence of apolipoprotein e

Journal of Alzheimer's Disease : JAD
Thomas Adi Kurnia SusantoJuan Zhou

Abstract

Knowledge of Alzheimer's disease (AD) manifestation in the pre-dementia stage facilitates the selection of appropriate measures for early detection and disease progression. To examine the trajectories of cognitive performance, gray matter volume (GMV), and cerebrospinal fluid (CSF) biomarkers, together with the influence of apolipoprotein E (APOE) in subjects with amyloid-β (Aβ) deposits across the pre-clinical to dementia stages of AD. 356 subjects were dichotomized into Aβ+ and Aβ- groups based on their CSF Aβ1-42 level. We derived AD-related atrophic regions (AD-ROIs) using the voxel-based morphometry approach. We characterized the trajectories of cognitive scores, GMV at AD-ROIs, and CSF biomarkers from preclinical to disease stages in Aβ+ subjects. The effect of APOE ε4 genotype on these trajectories was examined. Impairments in executive functioning/processing speed (EF/PS) and atrophy at the right supramarginal/inferior parietal gyrus were detected in cognitively normal Aβ+ subjects. Together with the APOE ε4 carrier status, these measures showed potential to identify cognitively normal elderly with abnormal CSF Aβ1-42 level in another independent cohort. Subsequently, impairment in memory, visuospatial, language, and at...Continue Reading

Citations

Jul 15, 2016·PloS One·Luise Christine LöweUNKNOWN Alzheimer’s Disease Neuroimaging Initiative
Mar 5, 2015·Journal of Alzheimer's Disease : JAD·Orestes Vicente ForlenzaAntonio Lucio Teixeira
Jan 7, 2017·Journal of Alzheimer's Disease : JAD·Linda J C van Waalwijk van DoornMarcel M Verbeek
Jan 23, 2020·Archives of Clinical Neuropsychology : the Official Journal of the National Academy of Neuropsychologists·Grant L IversonNoah D Silverberg
Mar 28, 2017·Alzheimer's & Dementia : the Journal of the Alzheimer's Association·Michael W WeinerUNKNOWN Alzheimer's Disease Neuroimaging Initiative
Jun 20, 2017·Dementia and Geriatric Cognitive Disorders Extra·Gaetano CorsoAlfonso Di Costanzo
Nov 1, 2016·Neurorehabilitation and Neural Repair·Weihong YuanShari L Wade
Nov 15, 2020·Ageing Research Reviews·Scott Ayton, Ashley I Bush

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