Cognition in schizophrenia: impairments, determinants, and functional importance

The Psychiatric Clinics of North America
Christopher R Bowie, Philip D Harvey

Abstract

Recent findings support and add to earlier findings of cognitive dysfunction in schizophrenia. Deficits across neurocognitive domains such as attention, working memory, language skills, and executive functioning tend to be moderate, with the most pronounced deficits found in verbal learning and memory. All these neurocognitive domains are related to adaptive and social skills, with executive functions and verbal learning and memory showing more variance across more domains than other neuro-cognitive variables. Negative symptoms and neurocognitive domains, although correlated, are distinct and have differential pathways of change with treatment. General psychopathology symptoms, such as depression and anxiety, may become important treatment targets as strategies are developed for translating cognitive enhancement to real-world functional performance.

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Related Concepts

Antipsychotic Effect
Biochemical Pathway
Memory Loss
Schizophrenia
Acquired Language Disorders
Memory for Designs Test
Social Perception
Psychopathology
Cognition Disorders
Verbal Learning

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