Abstract
Impaired awareness of hypoglycemia (IAH) and recurrent severe hypoglycemia (RSH) remain problematic for people with type 1 diabetes (T1D), despite major therapeutic advances. We explored beliefs around hypo- and hyperglycemia in adults with T1D with, and without, IAH and RSH. A cross-sectional U.S. multicenter survey included Attitudes to Awareness of Hypoglycemia (A2A; a 19-item questionnaire concerning beliefs about hypoglycemia), the Gold score (single item: awareness of hypoglycemia), and a question about severe hypoglycemia over the preceding year. The survey was emailed to 6,200 adult participants of the annual T1D Exchange clinic registry data collection. A2A data were subjected to principal component analysis with varimax rotation. Among 1,978 respondents (response rate 32%), 61.7% were women, mean ± SD age was 39.6 ± 16.3 years, and T1D duration was 23.1 ± 13.8 years. Thirty-seven percent reported IAH, 16% RSH, and 9% both. A2A items segregated into three factors, differently distributed by hypoglycemia experience. Respondents with IAH or RSH expressed appropriate concern about hypoglycemia, but those with IAH were more likely to prioritize hyperglycemia concerns than those with intact awareness (P = 0.002). Those with...Continue Reading
References
Feb 1, 1991·Diabetes·S R Heller, P E Cryer
Apr 1, 1995·Diabetes Care·W L ClarkeW Polonsky
Jul 30, 1994·Lancet·I CranstonS A Amiel
Jul 1, 1994·Diabetes Care·A E GoldB M Frier
Dec 1, 1994·Diabetes·S Dagogo-JackP E Cryer
Nov 1, 1993·Diabetes·C G FanelliP Bottini
Sep 24, 2004·Diabetes/metabolism Research and Reviews·Ulrik Pedersen-BjergaardBirger Thorsteinsson
Apr 5, 2008·Diabetic Medicine : a Journal of the British Diabetic Association·J GeddesB M Frier
Apr 25, 2009·Diabetes Care·Charlotte B SmithStephanie A Amiel
Sep 15, 2011·Diabetic Medicine : a Journal of the British Diabetic Association·H A RogersS A Amiel
May 24, 2012·Diabetes Care·David HopkinsSimon Heller
Aug 4, 2012·Diabetes Technology & Therapeutics·Jaclyn A ShepardBoris Kovatchev
Aug 28, 2012·Diabetes Care·Philip E Cryer
Sep 22, 2012·The Journal of Clinical Endocrinology and Metabolism·Roy W BeckUNKNOWN T1D Exchange Clinic Network
Apr 17, 2013·Diabetes Care·Elizabeth R SeaquistRobert Vigersky
Jun 14, 2013·The Journal of Clinical Endocrinology and Metabolism·Ruth S WeinstockUNKNOWN T1D Exchange Clinic Network
Nov 5, 2013·Diabetes/metabolism Research and Reviews·S A LittleJ A M Shaw
Dec 10, 2013·Diabetes Care·Nicole de ZoysaStephanie A Amiel
Feb 12, 2014·Diabetes Research and Clinical Practice·C HendrieckxJ Speight
May 24, 2014·Diabetes Care·Stuart A LittleJames A M Shaw
Jul 12, 2014·Diabetes Care·Jenise C WongUNKNOWN T1D Exchange Clinic Network
Dec 22, 2014·Acta Diabetologica·Therese AnderbroUnn-Britt Johansson
Jan 30, 2015·Diabetes Technology & Therapeutics·Katharine D BarnardDavid Kerr
May 23, 2015·Diabetes Care·Kellee M MillerUNKNOWN T1D Exchange Clinic Network
May 23, 2015·Diabetes Care·Pratik ChoudharyBernhard J Hering
Jul 25, 2015·Diabetes Care·Ester YeohStephanie A Amiel
Jan 1, 2014·SAGE Open Medicine·Jane SpeightJames Am Shaw
Nov 3, 2016·Journal of Diabetes Science and Technology·Peter M CalhounUNKNOWN In Home Closed Loop Study Group
Nov 23, 2016·Diabetes Care·UNKNOWN International Hypoglycaemia Study Group
Nov 22, 2017·Sleep Medicine·Sarah S JaserUNKNOWN T1D Exchange Clinic Network
Dec 1, 2017·The Journal of Clinical Endocrinology and Metabolism·Michael R RickelsMark H Schutta
Jul 6, 2018·Experimental and Clinical Endocrinology & Diabetes : Official Journal, German Society of Endocrinology [and] German Diabetes Association·Lutz HeinemannGuido Freckmann
Sep 12, 2018·The Diabetes Educator·Nancy M PetrySarit Polsky
Citations
Apr 9, 2020·Diabetes Technology & Therapeutics·Yu Kuei LinSimon J Fisher
May 14, 2020·Journal of Diabetes Investigation·Yu Kuei LinRodica Pop-Busui
Dec 18, 2020·Diabetes Care·Munachiso NwokoloPratik Choudhary
Jan 23, 2021·BMC Medical Informatics and Decision Making·Xia YuYehong Yang
Feb 8, 2021·Diabetologia·Stephanie A Amiel
Jan 27, 2021·The Journal for Nurse Practitioners : JNP
Apr 6, 2021·PloS One·Andrzej GawreckiAleksandra Araszkiewicz
Apr 11, 2021·Journal of Diabetes and Its Complications·W H PolonskyL Fisher