Cognitive abilities and 50- and 100-msec paired-click processes in schizophrenia.

The American Journal of Psychiatry
Ashley K SmithJose M Cañive

Abstract

Abnormal 50- and 100-msec event-related brain activity derived from paired-click procedures are well established in schizophrenia. There is little agreement on whether group differences in the ratio score, i.e., the ratio of EEG amplitude after the second stimulus (S2) to the amplitude after the first stimulus (S1), reflect an encoding or gating abnormality. In addition, the functional implications remain unclear. In the present study, EEG and magnetoencephalography (MEG) were used to examine paired-click measures and cognitive correlates of paired-click activity. EEG and whole-cortex MEG data were acquired during the standard paired-click paradigm in 73 comparison subjects and 79 schizophrenia patients. Paired-click ratio scores were obtained at 50 msec (P50 evoked potential at Cz, M50 at left and right superior temporal gyrus [STG]) and 100 msec (N100 at Cz, M100 at left and right STG). A cognitive battery assessing attention, working memory, and long-delay memory was administered. IQ was also estimated. Groups differed on ratio score and amplitude of S1 response. Ratio scores at 50 msec and 100 msec and S1 amplitude predicted variance in attention (primarily S1 amplitude), working memory, and long-delay memory. The attention...Continue Reading

Citations

Feb 9, 2013·Psychopharmacology·Robert E FeatherstoneSteven J Siegel
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Oct 29, 2015·Brain and Cognition·Chia-Hsiung ChengYung-Yang Lin
Mar 31, 2012·Human Brain Mapping·Andrew R MayerJose Cañive
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Nov 2, 2013·NeuroImage. Clinical·Yu-Han ChenJosé M Cañive
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