Cognitive ability in young adulthood and risk of dementia in a cohort of Danish men, brothers, and twins

Alzheimer's & Dementia : the Journal of the Alzheimer's Association
Merete OslerK Christensen

Abstract

We examined the association between cognitive ability in young adulthood and dementia in Danish men, brothers, and male twins. In total, 666,986 men born between 1939 and 1959 were identified for dementia diagnosis in national registries from 1969 to 2016. The association between cognitive ability from draft board examination and dementia was examined using Cox regression. During a 44-year follow-up, 6416 (0.96%) men developed dementia, 1760 (0.26%) and 970 (0.15%) of which were classified as Alzheimer's and vascular dementia, respectively. Low cognitive ability was associated with increased risk of dementia (hazard ratio [HR]per SD decrease 1.33 [95% confidence interval {CI} = 1.30-1.35]) with the strongest associations for vascular dementia (HRper SD decrease 1.47 [95% CI = 1.31-1.56]) and a weaker for Alzheimer's disease (HRper SD decrease 1.07 [95% CI = 1.03-1.13]). The intrabrother and twin analyses (taking shared family factors into account) showed attenuated risk estimates but with wide CIs. Low early-life cognitive ability increases the risk of dementia before the age of 78 years. The association is partly explained by shared family factors.

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Citations

Jan 16, 2019·JAMA Network Open·Alison R HuangSusan J Lapham
Oct 2, 2019·European Journal of Neurology : the Official Journal of the European Federation of Neurological Societies·M OslerE L Mortensen
Dec 20, 2017·Alzheimer's & Dementia : Diagnosis, Assessment & Disease Monitoring·Ara S Khachaturian
Sep 24, 2019·Twin Research and Human Genetics : the Official Journal of the International Society for Twin Studies·Dorthe Almind PedersenKaare Christensen
Jan 24, 2019·Proceedings of the National Academy of Sciences of the United States of America·William S KremenCarol E Franz
Aug 9, 2020·Frontiers in Psychiatry·Francisca S Rodriguez, Thomas Lachmann
Feb 12, 2020·ELife·Terese Sara Høj JørgensenMerere Osler
Apr 17, 2018·International Journal of Epidemiology·Gunhild Tidemann ChristensenMerete Osler
Jul 31, 2020·European Journal of Epidemiology·Merete OslerTerese Sara Høj Jørgensen
Apr 3, 2021·Nature Human Behaviour·Ian J DearyCatharine R Gale

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