Cognitive activities and cognitive performance in middle-aged adults at risk for Alzheimer's disease

Psychology and Aging
Erin M JonaitisMark A Sager

Abstract

Cognitive activity is thought to provide some protection against dementia, but the mechanism and timing of these effects are unknown. Data for this study were drawn from the Wisconsin Registry for Alzheimer's Prevention (WRAP), an at-risk middle-aged sample (mean age = 54 years) enriched for parental family history of Alzheimer's disease (AD). We had two main aims: (a) to determine the relative contribution of three facets of cognitive activity-education, occupational complexity with data, and cognitive leisure activities-to WRAP participants' cognitive performance; and (b) to assess for interactions between genetic risk factors and cognitive activity in explaining cognitive performance. Results from mixed effects models indicate that some of the variance usually attributed to education may be more closely accounted for by cognitive activities later in life. Overall, our analyses suggest cautious optimism for cognitive activities, especially game playing, as a strategy for preserving cognitive strengths in midlife.

Citations

Sep 17, 2015·Cadernos de saúde pública·Eliane Golfieri DiasMaria Lúcia Lebrão
Apr 13, 2017·Social Cognitive and Affective Neuroscience·Christopher R NicholasSterling C Johnson
Aug 15, 2018·Games for Health Journal·Noa Givon ShahamDebbie Rand
Jun 10, 2016·Journal of Occupational and Environmental Medicine·Joseph G GrzywaczMargie E Lachman
Jan 13, 2018·Alzheimer's & Dementia : Diagnosis, Assessment & Disease Monitoring·Sterling C JohnsonMark A Sager
Mar 24, 2020·Journal of the International Neuropsychological Society : JINS·Neika SharifianLaura B Zahodne
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Mar 27, 2021·Aging Clinical and Experimental Research·Allison CotterJeff Whittle

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