Sep 3, 2010

Cognitive activity and the cognitive morbidity of Alzheimer disease

Neurology
R S WilsonD A Evans

Abstract

To test the hypothesis that frequent cognitive activity predicts slower cognitive decline before dementia onset in Alzheimer disease (AD) and faster decline thereafter. As part of a longitudinal cohort study, older residents of a geographically defined population were assessed at 3-year intervals with brief cognitive performance tests from which a composite measure of global cognition was derived. After each wave of testing, a subset was sampled for clinical evaluation. The present analyses are based on 1,157 participants. They were free of dementia at study enrollment at which time they rated frequency of participation in common cognitively stimulating activities from which a previously validated summary measure was derived. They were sampled for clinical evaluation a mean of 5.6 years after enrollment and subsequently followed a mean of 5.7 years with brief cognitive performance testing at 3-year intervals. On clinical evaluation, 614 people had no cognitive impairment, 395 had mild cognitive impairment, and 148 had AD. During follow-up, the annual rate of global cognitive decline in persons without cognitive impairment was reduced by 52% (estimate = 0.029, SE = 0.010, p = 0.003) for each additional point on the cognitive act...Continue Reading

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Mentioned in this Paper

Familial Alzheimer Disease (FAD)
Morbidity Aspects
Memory for Designs Test
Alzheimer's Disease
Longitudinal Survey
Compress (Compression Algorithm)
Data Interpretation, Statistical
Mild Cognitive Disorder
Overinclusion
Cognition

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