Cognitive alterations in non-demented CADASIL patients

Cerebrovascular Diseases
H TailliaM G Bousser

Abstract

CADASIL is an inherited small-artery disease of the brain due to mutations of the Notch3 gene on chromosome 19. It is characterized by strokes, migraine with aura, and severe mood disturbances during mid adulthood and leads progressively to subcortical dementia. The precise onset of the cognitive decline in CADASIL remains unknown. We report here the cognitive evaluation of 8 non-demented symptomatic patients with CADASIL from 35 to 66 years of age. Altered performances were found in all subjects with the Wisconsin Card-Sorting Test (WCST), in 5/8 with the Trail-Making Test, and in 3/8 with copying of Rey's figure. Altered performances with codes and similarities of the WAIS-R, the Wechsler Memory Scale, Raven's Progressive Matrices, and the category and letter fluency task were observed less frequently (n < or = 2). The score obtained with the WCST was not significantly correlated with the severity of the white-matter or basal ganglia signal abnormalities at MRI examination. Our data show that: (1) symptomatic CADASIL patients, although non-demented, can present with a subtle cognitive impairment; (2) tasks involving the frontal lobes are found most frequently altered, and (3) this subtle cognitive deficit can develop in the a...Continue Reading

Citations

Jun 30, 2006·Journal of Neurology·Saif S M Razvi, Ian Bone
Sep 4, 1999·Neuropathology and Applied Neurobiology·H KalimoB Winblad
Apr 29, 2006·European Journal of Neurology : the Official Journal of the European Federation of Neurological Societies·R ScheidO Sabri
May 20, 2000·Annals of the New York Academy of Sciences·M Viitanen, H Kalimo
Jan 20, 2006·Journal of Neurology, Neurosurgery, and Psychiatry·F BuffonH Chabriat
Jan 20, 2006·Journal of Neurology, Neurosurgery, and Psychiatry·L Caeiro, J M Ferro
Jan 18, 2002·Journal of Neurology, Neurosurgery, and Psychiatry·J H KramerH C Chui
Aug 30, 2008·Srpski arhiv za celokupno lekarstvo·Jasna Zidverc-TrajkovićNadezda Sternić
Jun 23, 2009·Lancet Neurology·Hugues ChabriatMarie-Germaine Bousser
Oct 10, 2006·Revue neurologique·A MouradH Chabriat
Oct 18, 2014·Brain Pathology·Saara TikkaHannu Kalimo
Jul 15, 2011·Arquivos de neuro-psiquiatria·Júlio César Vasconcelos da SilvaCharles André
Nov 4, 2010·Journal of Geriatric Psychiatry and Neurology·D Hervé, H Chabriat
Jun 4, 1999·Stroke; a Journal of Cerebral Circulation·D W DesmondJ P Mohr
May 15, 2004·Stroke; a Journal of Cerebral Circulation·Kaarina AmberlaMatti Viitanen
Feb 3, 2007·Stroke; a Journal of Cerebral Circulation·Michael K LiemSaskia A J Lesnik Oberstein
Apr 30, 2020·European Journal of Neurology : the Official Journal of the European Federation of Neurological Societies·H ChabriatM G Bousser
May 14, 2010·Arquivos de neuro-psiquiatria·Charles André
Dec 15, 2020·Journal of Neuroimaging : Official Journal of the American Society of Neuroimaging·Stefano OrsoliniStefano Diciotti

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