Cognitive and functional deficits in people with schizophrenia: Evidence for accelerated or exaggerated aging?

Schizophrenia Research
Philip D Harvey, Jennifer B Rosenthal

Abstract

Cognitive and functional deficits are commonly seen in people with schizophrenia. The profile of these impairments has a resemblance to the cognitive changes seen in healthy aging. In specific, many of the cognitive ability domains that change the most with aging in healthy people are the most salient of these deficits seen in people with schizophrenia, including prominent deficits in processing speed, working memory, and episodic memory. Functional deficits seen in schizophrenia are also similar to those seen in healthy aging. There is a relationship between multiple psychotic relapses and treatment resistance and longitudinal cognitive and functional changes in schizophrenia, with this relationship starting early in the course of illness. Cognitive performance in people with schizophrenia may be consistent with accelerated or premature aging. People with schizophrenia perform similarly to healthy people who are 3 or more decades older on indices of both cognition and their everyday functional skills. Some people with schizophrenia show exaggerated cognitive changes as well. Cognitive and functional performance worsens at the outset of the illness in schizophrenia compared to premorbid functioning, meaning that these deficits ...Continue Reading

Citations

Jun 25, 2020·Clinics·Helena BelliniJosé Gallucci-Neto
Sep 23, 2020·NPJ Schizophrenia·Mohamed A SherifWilliam W Lytton
Jul 31, 2019·Scandinavian Journal of Medicine & Science in Sports·Mona NygårdJørn Heggelund
Jan 15, 2021·Early Intervention in Psychiatry·Mariapaola BarbatoMaryam A AlJassmi
Jan 18, 2020·Schizophrenia Research·Martino Belvederi MurriLuigi Grassi
Feb 4, 2021·Current Opinion in Psychiatry·Haley V SolomonLynn E DeLisi
Apr 4, 2021·International Journal of Environmental Research and Public Health·Maria MoudatsouAreti Stavropoulou
Jan 26, 2020·Cortex; a Journal Devoted to the Study of the Nervous System and Behavior·Flavien ThuaireMarie Izaute
May 25, 2020·Psychiatry Research·Madeleine JohanssonLars Helldin
Jul 10, 2021·Frontiers in Psychiatry·Lijuan HuoXiang Yang Zhang
Jul 26, 2021·Journal of Psychiatric Research·Marco SpangaroRoberto Cavallaro
Jul 19, 2021·Asian Journal of Psychiatry·N A UranovaV I Rakhmanova

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