Nov 7, 2012

Cognitive and functional resilience despite molecular evidence of Alzheimer's disease pathology

Alzheimer's & Dementia : the Journal of the Alzheimer's Association
Selam NegashSteven E Arnold

Abstract

The correlation between neuropathological lesions and cognition is modest. Some individuals remain cognitively intact despite the presence of significant Alzheimer's disease (AD) pathology, whereas others manifest cognitive symptoms and dementia in the same context. The aim of the present study was to examine cognitive and cerebral reserve factors associated with resilient functioning in the setting of AD pathology. University of Pennsylvania Alzheimer's Disease Center research participants with biochemical biomarker evidence of AD pathology (cerebrospinal fluid amyloid-β1-42 <192 pg/mL) and comparable medial temporal lobe atrophy were categorized by Clinical Dementia Rating Scale-Sum of Boxes (CDR-SOB) score as AD dementia (CDR-SOB >1) or AD resilient (CDR-SOB ≤0.5). Groups were compared for a variety of demographic, clinical, and neuroimaging variables to identify factors that are associated with resilience to AD pathology. A univariate model identified education and intracranial volume (ICV) as significant covariates. In a multivariate model with backward selection procedure, ICV was retained as a factor most significantly associated with resilience. The interaction term between ICV and education was not significant, suggest...Continue Reading

  • References24
  • Citations9

References

Mentioned in this Paper

Senile Paranoid Dementia
Familial Alzheimer Disease (FAD)
Neurobehavioral Manifestations
Abnormal Degeneration
APP protein, human
Autopsy
Bulla
Neurons
Malignant Neoplasm of Temporal Lobe
Brain

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