PMID: 8942970Nov 26, 1996Paper

Cognitive and neurobiologic markers of early Alzheimer disease

Proceedings of the National Academy of Sciences of the United States of America
M S Albert

Abstract

Recent studies indicate that impairments in two cognitive domains characterize the cognitive abnormalities that appear earliest in the course of Alzheimer disease (AD). These cognitive domains pertain to memory and executive function ability; in particular, memory test scores reflecting the difference between immediate and delayed recall and tasks that assess cognitive flexibility (e.g., set-shifting). Preliminary data indicate that tasks of this nature, along with specific genetic information (i.e., APOE-4 status), are important in identifying which individuals with recent cognitive changes (considered to have "questionable" disease) will progress to the point where they meet criteria for AD over time. When this cognitive and genetic information is combined with neuroimaging measures targeted at the brain regions demonstrating pathology early in AD, it may serve as specific and accurate prognostic markers of AD.

References

Dec 31, 1976·Archiv für Psychiatrie und Nervenkrankheiten·A Brun, L Gustafson
Feb 1, 1992·Neurology·R C PetersenE G Tangalos
Apr 1, 1989·Archives of Neurology·M Storandt, R D Hill
Oct 1, 1989·Journal of Clinical and Experimental Neuropsychology·W Milberg, M Albert
Oct 1, 1988·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·J P SeabT F Budinger
Dec 1, 1988·Journal of Clinical and Experimental Neuropsychology·J T Becker
Mar 1, 1988·Journal of Clinical and Experimental Neuropsychology·R G Morris, A D Baddeley
Feb 1, 1988·Brain and Cognition·R P HartJ R Taylor
Oct 1, 1986·Annals of Neurology·B T HymanA R Damasio
Nov 1, 1986·The Quarterly Journal of Experimental Psychology. A, Human Experimental Psychology·A BaddeleyH Spinnler
Dec 1, 1983·Journal of Clinical Neuropsychology·R S WilsonA W Kaszniak
Jan 1, 1993·The Psychiatric Quarterly·A ConvitH Wisniewski
Feb 1, 1993·Annals of Neurology·S W Scheff, D A Price
Mar 1, 1993·Proceedings of the National Academy of Sciences of the United States of America·W J StrittmatterA D Roses
Jun 7, 1985·Science·D A Paige, A P Ingersoll

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Citations

May 17, 2005·European Archives of Psychiatry and Clinical Neuroscience·Reinhard HeunFrank Jessen
Jun 1, 2010·Brain Structure & Function·Jonathan D ThiessenBenedict C Albensi
Feb 15, 2011·Brain Structure & Function·Igor YakushevAndreas Fellgiebel
Mar 20, 2002·Current Neurology and Neuroscience Reports·C JanusD Westaway
Sep 19, 2006·Archives of Clinical Neuropsychology : the Official Journal of the National Academy of Neuropsychologists·Laura A RabinAndrew J Saykin
Aug 18, 2004·Neurobiology of Aging·Christopher JanusDavid Westaway
Sep 22, 2001·Physiology & Behavior·C Janus, D Westaway
Sep 12, 2006·Journal of the International Neuropsychological Society : JINS·Elizabeth W TwamleyMark W Bondi
Jun 8, 2013·Journal of the International Neuropsychological Society : JINS·Yan ZengShawn M McClintock
Apr 4, 2002·The Australian and New Zealand Journal of Psychiatry·Alexander Collie, Paul Maruff
May 29, 2009·Alzheimer Disease and Associated Disorders·Sandra WeintraubJohn C Morris
Apr 5, 2012·Cold Spring Harbor Perspectives in Medicine·Sandra WeintraubDavid P Salmon
Feb 3, 1999·Annual Review of Genetics·D L PriceS S Sisodia
Mar 19, 2005·Dementia and Geriatric Cognitive Disorders·Ariela GigiUri Hadar
May 10, 2006·Dementia and Geriatric Cognitive Disorders·Corina PennanenHilkka Soininen
Jul 12, 2007·Dementia and Geriatric Cognitive Disorders·Pamela L Sheridan, Jeffrey M Hausdorff
Feb 19, 2013·Brain Structure & Function·Sarah E Crowe, Graham C R Ellis-Davies
Mar 25, 2005·Applied Neuropsychology·Shirley FecteauPascal Belin
Sep 14, 2000·Proceedings of the National Academy of Sciences of the United States of America·B Fischl, A M Dale
Oct 28, 2008·Brain : a Journal of Neurology·D BocheJ A R Nicoll
Jun 8, 2007·Proceedings of the National Academy of Sciences of the United States of America·El MusHenri Tiedge
Nov 1, 2005·The Spanish Journal of Psychology·Igor I Stepanov, Charles I Abramson
Nov 26, 1996·Proceedings of the National Academy of Sciences of the United States of America·P S Goldman-Rakic
Jul 30, 2003·Genes, Brain, and Behavior·J C DodartS M Paul
Sep 8, 2011·Nature Reviews. Neuroscience·Scott A SmallCarol A Barnes
Feb 5, 2013·Medical Hypotheses·Silvia Serino, Giuseppe Riva
Mar 23, 2011·Journal of Neuroscience Methods·Bechara J SaabJohn C Roder
Dec 7, 2010·Behavioural Brain Research·Robbert HavekesEddy A Van der Zee
Oct 24, 2007·Brain and Cognition·Diego Fernandez-Duque, Sandra E Black
Nov 14, 2006·Neurobiology of Aging·Tero TapiolaHilkka Soininen

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