Cognitive and olfactory deficits in Machado-Joseph disease: a dopamine transporter study

Parkinsonism & Related Disorders
Pedro Braga-NetoOrlando Graziani Povoas Barsottini

Abstract

Cognitive and olfactory impairments have been demonstrated in patients with Machado-Joseph disease (MJD), and a possible relationship with dopaminergic dysfunction is implicated. However, there is still controversy regarding the pattern of striatal dopaminergic dysfunction in patients with MJD. In this study, we investigated whether these patients had different dopamine transporter (DAT) densities as compared to healthy subjects, and correlated these data with cognitive performance and sense of smell. Twenty-two MJD patients and 20 control subjects were enrolled. The neuropsychological assessment comprised the spatial span, symbol search, picture completion, stroop color word test, trail making test and phonemic verbal fluency test. The 16-item Sniffin' Sticks was used to evaluate odor identification. DAT imaging was performed using the SPECT radioligand [(99m)Tc]-TRODAT-1, alongside with Magnetic Resonance imaging. Patients with MJD showed significantly lower DAT density in the caudate (1.34 ± 0.27 versus 2.02 ± 0.50, p < 0.001), posterior putamen (0.81 ± 0.32 versus 1.32 ± 0.34, p < 0.001) and anterior putamen (1.10 ± 0.31 versus 1.85 ± 0.45, p < 0.001) compared with healthy controls. The putamen/caudate ratio was also signif...Continue Reading

References

Jan 1, 1997·Journal of the Neurological Sciences·T TaniwakiI Goto
Apr 1, 1997·European Journal of Nuclear Medicine·M P KungH F Kung
Oct 8, 2003·Movement Disorders : Official Journal of the Movement Disorder Society·Paola P Piccini
Apr 22, 2004·Lancet Neurology·Ludger SchölsOlaf Riess
Jul 21, 2004·Parkinsonism & Related Disorders·Chin-Song LuYah-Huei Wu Chou
Nov 13, 2004·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Daniel GotiVeronica Colomer
Aug 31, 2006·Movement Disorders : Official Journal of the Movement Disorder Society·Matthias ReimoldKatrin Bürk
Mar 5, 2008·Current Opinion in Neurology·Udo RübThomas Deller
Feb 16, 2010·Cortex; a Journal Devoted to the Study of the Nervous System and Behavior·Catherine J Stoodley, Jeremy D Schmahmann
Sep 3, 2010·Journal of Neurology·Esther CuboJosé A Obeso
Mar 4, 2011·Parkinsonism & Related Disorders·P Braga-NetoO G P Barsottini
May 3, 2011·Current Opinion in Neurobiology·Roshan Cools

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Citations

Feb 16, 2013·The Cerebellum·Karen A G TakazakiMarcondes C França
Jun 7, 2013·Brain : a Journal of Neurology·José Luiz PedrosoOrlando G P Barsottini
Feb 21, 2014·Acta Neuropathologica·Johannes AttemsKurt A Jellinger
Feb 26, 2016·Cerebellum & Ataxias·Irene Pulido-ValdeolivasJavier Arpa
Dec 8, 2014·Cortex; a Journal Devoted to the Study of the Nervous System and Behavior·Lorenzo PiaAnna Berti
Jun 19, 2013·Movement Disorders : Official Journal of the Movement Disorder Society·José Luiz PedrosoOrlando Graziani P Barsottini
Mar 30, 2016·The Cerebellum·Alberto R M MartinezMarcondes C França
May 18, 2013·Parkinsonism & Related Disorders·José Luiz PedrosoOrlando Graziani Povoas Barsottini
May 5, 2016·Parkinsonism & Related Disorders·Barbara BorroniLoredana Boccone
Jul 16, 2016·The Clinical Neuropsychologist·Erin E RobertsonJoan A O'Keefe
Apr 21, 2016·Arquivos de neuro-psiquiatria·Hélio A G TeiveRenato P Munhoz
Sep 6, 2019·Cerebellum & Ataxias·Adriana MoroRenato P Munhoz

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