Cognitive and physical activity and dementia: A 44-year longitudinal population study of women

Neurology
Jenna NajarIngmar Skoog

Abstract

To investigate whether cognitive and physical activities in midlife are associated with reduced risk of dementia and dementia subtypes in women followed for 44 years. A population-based sample of 800 women aged 38-54 years (mean age 47 years) was followed from 1968 to 2012. Cognitive (artistic, intellectual, manual, religious, and club) and physical activity were assessed at baseline. During follow-up, dementia (n = 194), Alzheimer disease (n = 102), vascular dementia (n = 27), mixed dementia (n = 41), and dementia with cerebrovascular disease (n = 81) were diagnosed according to established criteria based on information from neuropsychiatric examinations, informant interviews, hospital records, and registry data. Cox regression models were used with adjustment for age, education, socioeconomic status, hypertension, body mass index, cigarette smoking, diabetes mellitus, angina pectoris, stress, and major depression. We found that cognitive activity in midlife was associated with a reduced risk of total dementia (hazard ratio [HR] 0.66; 95% confidence interval [CI] 0.49-0.89) and Alzheimer disease (HR 0.54; 95% CI 0.36-0.82) during follow-up. Physical activity in midlife was associated with a reduced risk of mixed dementia (HR 0...Continue Reading

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Citations

Sep 15, 2019·Alzheimer's & Dementia : the Journal of the Alzheimer's Association·Caleb E Finch, Alexander M Kulminski
Mar 12, 2020·Alzheimer's & Dementia : the Journal of the Alzheimer's Association
Jun 24, 2020·Alzheimer's & Dementia : the Journal of the Alzheimer's Association·Jenna NajarIngmar Skoog
Sep 6, 2020·Antioxidants·D Allan Butterfield, Debra Boyd-Kimball
Feb 11, 2020·Journal of Alzheimer's Disease : JAD·Kaitlin B CasalettoLaura B Zahodne
Jul 31, 2020·European Journal of Applied Physiology·Anna PedrinollaFederico Schena
Jan 17, 2020·Aging Medicine·Xianbo Zhou, J Wesson Ashford
Aug 8, 2020·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Cindy K Barha, Teresa Liu-Ambrose
Jul 2, 2019·The Canadian Journal of Nursing Research = Revue Canadienne De Recherche En Sciences Infirmières·Shannon HallowayAnnabelle S Volgman
Jul 19, 2019·Frontiers in Aging Neuroscience·Hura BehforuziKirk R Daffner
Oct 22, 2019·Alzheimer's Research & Therapy·Oskar HanssonTomas Deierborg
Aug 4, 2020·Journal of Alzheimer's Disease : JAD·Sander LamballaisM Arfan Ikram
Apr 8, 2020·Frontiers in Aging Neuroscience·So Yeon JeonDong Young Lee
May 30, 2020·Alzheimer Disease and Associated Disorders·Drew GourleyHirofumi Tanaka
Oct 2, 2020·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·A Zarina KraalLaura B Zahodne
Nov 16, 2020·Experimental Gerontology·Natan FeterAirton J Rombaldi
Feb 4, 2021·Alzheimer's & Dementia : Diagnosis, Assessment & Disease Monitoring·Jenna NajarAnna Zettergren
Dec 17, 2020·European Journal of Epidemiology·Sander LamballaisMohammad Arfan Ikram
Mar 24, 2021·Alzheimer's & Dementia : the Journal of the Alzheimer's Association
May 4, 2021·Journal of Alzheimer's Disease : JAD·Taylor J KrivanekKirk R Daffner
Jun 22, 2021·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·Catherine O'Brien, Roee Holtzer
Aug 21, 2021·Frontiers in Cellular Neuroscience·Rui XuZhen-Ni Guo
Jul 6, 2021·Menopause : the Journal of the North American Menopause Society·Jenna NajarIngmar Skoog
Aug 14, 2021·The Journals of Gerontology. Series B, Psychological Sciences and Social Sciences·Kyle D MooredMichelle C Carlson
Oct 12, 2021·European Journal of Nutrition·Jessica SamuelssonAnna Zettergren
Nov 19, 2021·Acta Neurologica Scandinavica·Charlotte HoltbackPer-Olof Hansson

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