Cognitive and psychomotor effects of three months of escitalopram treatment in elderly patients with major depressive disorder

Journal of Affective Disorders
Lieve Lia BeheydtBernard Sabbe

Abstract

Although psychomotor retardation (PR) and cognitive disfunctioning are essential symptoms of elderly depressed patients, the differential effect of treatment with an SSRI in the elderly on these symptoms has hardly got any attention in studies with objective experimental measures. Since effects appear relatively slower in elderly, this study evaluates the effect on cognitive and psychomotor functioning as compared to mood, on four points during a twelve week follow up of monotreatment with escitalopram. 28 non-demented elderly unipolar depressive patients on 5-20mg escitalopram were compared to 20 matched healthy elderly. All participants underwent a test battery containing clinical depression measures, cognitive measures of processing speed, executive function and memory, clinical ratings of PR, and objective computerized fine motor skill-tests at the start and after 2, 6 and 12 weeks. Statistical analysis consisted of a General Linear Model (GLM) repeated measures multivariate analysis of variance of completers to compare the psychomotor and cognitive outcomes of the two groups. Although, apart from the significant mood effect, no interaction effects were found for the psychomotor and cognitive tasks, the means in general sho...Continue Reading

References

Jul 1, 1983·Archives of General Psychiatry·M F FolsteinJ E Helzer
Jan 1, 1982·Journal of Psychiatric Research·J A YesavageV O Leirer
Oct 14, 1996·Journal of Affective Disorders·B SabbeF Zitman
Aug 6, 1999·Archives of General Psychiatry·B Kalayam, G S Alexopoulos
Feb 16, 2000·Acta Psychiatrica Scandinavica·G ParkerI Schweitzer
Jul 27, 2000·The American Journal of Psychiatry·G Parker
Oct 31, 2001·Neuropsychologia·Francisco Barceló, Robert T Knight
Jul 2, 2002·The American Journal of Psychiatry·Kathryn A LockwoodWilfred G van Gorp
Aug 17, 2002·Biological Psychiatry·George S AlexopoulosDavid W Oslin
Sep 3, 2002·Journal of Affective Disorders·Gordon ParkerDusan Hadzi-Pavlovic
Feb 1, 1960·Journal of Neurology, Neurosurgery, and Psychiatry·M HAMILTON
Mar 31, 2004·Acta Psychiatrica Scandinavica·R MerglU Hegerl
Oct 30, 2004·The American Journal of Psychiatry·Steven P RooseUNKNOWN Old-Old Depression Study Group
Sep 2, 2005·The American Journal of Psychiatry·Alex J Mitchell, Hari Subramaniam
Jan 19, 2007·Neuropsychobiology·Siegfried KasperHans de Swart
Jun 26, 2007·The American Journal of Geriatric Psychiatry : Official Journal of the American Association for Geriatric Psychiatry·Philip GorwoodCornelius Katona
Dec 18, 2007·Journal of Affective Disorders·Didier SchrijversBernard G C Sabbe
Jan 1, 2008·The American Journal of Geriatric Psychiatry : Official Journal of the American Association for Geriatric Psychiatry·Anjana BoseChetan Gandhi
Mar 10, 2009·Neuropsychobiology·D SchrijversB G C Sabbe
Jan 28, 2010·The American Journal of Geriatric Psychiatry : Official Journal of the American Association for Geriatric Psychiatry·Joel R SneedSteven P Roose
Nov 4, 2010·Progress in Neuro-psychopharmacology & Biological Psychiatry·Jeylan S BuyukduraPaul E Croarkin
Jul 5, 2012·Revista brasileira de fisioterapia·Kleyton T SantosSaulo V Rocha
Aug 7, 2012·The Journals of Gerontology. Series B, Psychological Sciences and Social Sciences·Tuo Yu ChenJerri D Edwards
Dec 29, 2013·Maturitas·Anya TopiwalaKlaus P Ebmeier
Feb 13, 2015·Frontiers in Psychiatry·Lieve Lia BeheydtBernard Sabbe

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.