Cognitive-Behavioral Analysis System of Psychotherapy, Drug, or Their Combination for Persistent Depressive Disorder: Personalizing the Treatment Choice Using Individual Participant Data Network Metaregression

Psychotherapy and Psychosomatics
Toshi A FurukawaElisabeth Schramm

Abstract

Persistent depressive disorder is prevalent, disabling, and often difficult to treat. The cognitive-behavioral analysis system of psychotherapy (CBASP) is the only psychotherapy specifically developed for its treatment. However, we do not know which of CBASP, antidepressant pharmacotherapy, or their combination is the most efficacious and for which types of patients. This study aims to present personalized prediction models to facilitate shared decision-making in treatment choices to match patients' characteristics and preferences based on individual participant data network metaregression. We conducted a comprehensive search for randomized controlled trials comparing any two of CBASP, pharmacotherapy, or their combination and sought individual participant data from identified trials. The primary outcomes were reduction in depressive symptom severity for efficacy and dropouts due to any reason for treatment acceptability. All 3 identified studies (1,036 participants) were included in the present analyses. On average, the combination therapy showed significant superiority over both monotherapies in terms of efficacy and acceptability, while the latter 2 treatments showed essentially similar results. Baseline depression, anxiety,...Continue Reading

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Citations

Mar 15, 2019·Epidemiology and Psychiatric Sciences·Toshi A FurukawaPim Cuijpers
Jan 23, 2019·Evidence-based Mental Health·Andrea Cipriani, Anneka Tomlinson
Apr 6, 2021·Frontiers in Psychology·Matthias DomhardtHarald Baumeister
May 2, 2021·Journal of the American Academy of Child and Adolescent Psychiatry·Annabeth P GroenmanUNKNOWN Prof. Dr. van den Hoofdakker share last authorship and contributed equally to this work.
Aug 24, 2020·The Lancet. Psychiatry·Elisabeth SchrammKatharina Domschke
Jul 8, 2021·Psychology, Health & Medicine·Tao JinXiaolong Wang
Sep 23, 2021·JAMA Psychiatry·Ronald C Kessler, Alex Luedtke
Jan 5, 2022·Journal of Psychoactive Drugs·Brianna R AltmanJoseph De Leo

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