Cognitive behavioral therapy and tai chi reverse cellular and genomic markers of inflammation in late-life insomnia: a randomized controlled trial

Biological Psychiatry
Michael R IrwinSteve Cole

Abstract

Sleep disturbance is associated with activation of systemic and cellular inflammation, as well as proinflammatory transcriptional profiles in circulating leukocytes. Whether treatments that target insomnia-related complaints might reverse these markers of inflammation in older adults with insomnia is not known. In this randomized trial, 123 older adults with insomnia were randomly assigned to cognitive-behavioral therapy for insomnia (CBT-I), tai chi chih (TCC), or sleep seminar education active control condition for 2-hour sessions weekly over 4 months with follow-up at 7 and 16 months. We measured C-reactive protein (CRP) at baseline and months 4 and 16; toll-like receptor-4 activated monocyte production of proinflammatory cytokines at baseline and months 2, 4, 7, and 16; and genome-wide transcriptional profiling at baseline and month 4. As compared with sleep seminar education active control condition, CBT-I reduced levels of CRP (months 4 and 16, ps < .05), monocyte production of proinflammatory cytokines (month 2 only, p < .05), and proinflammatory gene expression (month 4, p < .01). TCC marginally reduced CRP (month 4, p = .06) and significantly reduced monocyte production of proinflammatory cytokines (months 2, 4, 7, and...Continue Reading

Associated Clinical Trials

Jan 20, 2006·Michael Irwin, M.D.

References

Jan 18, 2003·Sleep Medicine Reviews·Maurice M Ohayon
Mar 26, 2003·Psychosomatic Medicine·Charles M MorinHans Ivers
Apr 10, 2003·JAMA : the Journal of the American Medical Association·Katherine EspositoDario Giugliano
Dec 11, 2003·JAMA : the Journal of the American Medical Association·Howard D SessoPaul M Ridker
Feb 21, 2004·Journal of the American College of Cardiology·Hans K Meier-EwertJanet M Mullington
May 27, 2004·Journal of the American Geriatrics Society·Fuzhong LiCheryl Weimer
Aug 18, 2004·Sleep Medicine Reviews·M H Bonnet, D L Arand
Sep 30, 2004·Nature Immunology·Donald N CookDavid A Schwartz
Oct 30, 2004·The American Journal of Psychiatry·Eric A NofzingerDavid J Kupfer
Aug 9, 2005·Brain, Behavior, and Immunity·Ivonne BurgosDieter Riemann
Sep 2, 2005·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Josée SavardCharles M Morin
Feb 2, 2006·Health Psychology : Official Journal of the Division of Health Psychology, American Psychological Association·Michael R IrwinPerry M Nicassio
Mar 15, 2006·International Journal of Obesity : Journal of the International Association for the Study of Obesity·J I BarzilayA B Newman
Sep 20, 2006·Archives of Internal Medicine·Michael R IrwinSteve Cole
Dec 15, 2006·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·Sarosh J MotivalaMichael R Irwin
Mar 16, 2007·Brain, Behavior, and Immunity·Michael R Irwin, Andrew H Miller
Apr 3, 2007·Journal of the American Geriatrics Society·Michael R IrwinMichael N Oxman
Jun 20, 2008·Biological Psychiatry·Michael R IrwinSteve Cole
Sep 4, 2008·The American Journal of Psychiatry·Hyong Jin ChoMichael R Irwin
Nov 20, 2008·Journal of the American Geriatrics Society·Barbara J NicklasMarco Pahor
May 21, 2009·JAMA : the Journal of the American Medical Association·Charles M MorinLucie Baillargeon
May 28, 2009·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Steven W Cole
May 28, 2009·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Brandon L PierceCornelia M Ulrich
Jun 2, 2009·Sleep Medicine Reviews·Dieter RiemannChristoph Nissen
Jun 13, 2009·Brain, Behavior, and Immunity·Michael R IrwinRichard Olmstead
Jul 2, 2009·Medicine and Science in Sports and Exercise·Peter T CampbellCornelia M Ulrich
Dec 1, 2009·Sleep Medicine Reviews·Dieter Riemann
Aug 20, 2010·Biological Psychiatry·Naomi I EisenbergerMichael R Irwin
Sep 8, 2010·The New England Journal of Medicine·Chenchen WangTimothy McAlindon
Feb 9, 2011·Journal of Affective Disorders·Chiara BaglioniDieter Riemann
Feb 9, 2011·Proceedings of the National Academy of Sciences of the United States of America·Steven W ColeJohn T Cacioppo
Mar 2, 2011·The American Journal of Geriatric Psychiatry : Official Journal of the American Association for Geriatric Psychiatry·Helen LavretskyMichael R Irwin
Aug 6, 2011·Nature Reviews. Immunology·Michael R Irwin, Steven W Cole
Sep 22, 2011·The American Journal of Geriatric Psychiatry : Official Journal of the American Association for Geriatric Psychiatry·Michael R Irwin, Richard Olmstead
Nov 11, 2011·Pflügers Archiv : European journal of physiology·Luciana BesedovskyJan Born
Nov 18, 2011·Biological Psychiatry·Michael H AntoniSteven W Cole
Jan 10, 2012·Annual Review of Immunology·Giorgio Trinchieri

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Citations

Oct 27, 2015·Current Sleep Medicine Reports·Samantha Conley, Nancy S Redeker
Jun 28, 2015·Brain, Behavior, and Immunity·Julienne E Bower, Michael R Irwin
Jul 26, 2014·Annual Review of Psychology·Michael R Irwin
Oct 27, 2015·Biological Psychiatry·Richard J Davidson
Nov 3, 2015·The Lancet. Psychiatry·Steven MoylanMichael Berk
Dec 30, 2016·Journal of Evaluation in Clinical Practice·Herman A van WietmarschenJan van der Greef
Dec 22, 2016·Brain Sciences·Mackenzie J Lind, Philip R Gehrman
Jun 19, 2015·Sleep·Sairam ParthasarathyDaniel Combs
May 11, 2017·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Michael R IrwinJulienne E Bower
Apr 14, 2017·JCI Insight·Samuel BrodFulvio D'Acquisto
Jan 23, 2018·Neurorehabilitation and Neural Repair·Somporn SungkaratNipon Chattipakorn
Apr 5, 2018·The Journal of Alternative and Complementary Medicine : Research on Paradigm, Practice, and Policy·Manoj K BhasinTowia A Libermann
Mar 29, 2019·Physiological Reviews·Luciana BesedovskyMonika Haack
Jun 18, 2019·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Monika HaackJanet Mullington
Sep 6, 2018·Current Medicinal Chemistry·Mireille Salas-CrisóstomoEric Murillo-Rodríguez
Mar 4, 2019·Current Psychiatry Reports·Judith E CarrollLisa M Christian
Aug 10, 2016·Multiple Sclerosis : Clinical and Laboratory Research·Giuseppe LanzaLuigi Ferini-Strambi
Jan 5, 2020·Annual Review of Public Health·Kelly E RentscherColter Mitchell
Apr 24, 2020·Psychological Medicine·Michael R DolsenBrenda W J H Penninx
Jul 11, 2019·Nature Reviews. Immunology·Michael R Irwin
Aug 2, 2017·Proceedings of the National Academy of Sciences of the United States of America·David S CurtisCarol D Ryff
Aug 25, 2016·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Andrew H MillerJennifer C Felger
Aug 12, 2016·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Michael R Irwin, Mark R Opp
Feb 28, 2019·Laboratory Investigation; a Journal of Technical Methods and Pathology·Yan LiuRaymond Chuen-Chung Chang
May 21, 2019·Current Sleep Medicine Reports·Joseph M DzierzewskiBruce Rybarczyk
Aug 28, 2020·Frontiers in Psychology·Sabrina VendittiMichele Zampieri
Sep 26, 2019·The World Journal of Biological Psychiatry : the Official Journal of the World Federation of Societies of Biological Psychiatry·S Melanie LeeJoshua H Cho
Nov 7, 2018·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Kholoud M El-ShewyMohamed M Abdel-Daim

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Methods Mentioned

BETA
pharmacotherapy

Software Mentioned

Transcript Origin Analyses
TRANSFAC
TELiS
Transcript Origin Analysis
SPSS

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